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The Importance of Regulation in Natural Immunity to HIV

Axe Immunopathologie, Centre de Recherche du Centre Hospitalier de l’Université de Montréal (CRCHUM), Montréal, QC H2X0A9, Canada
Département de Microbiologie, Infectiologie et Immunologie de l‘Université de Montréal, Montréal, QC H3C3J7, Canada
Institut National de Santé Publique du Québec, Montréal, QC H2P1E2, Canada
Authors to whom correspondence should be addressed.
Academic Editor: Michael Bukrinsky
Vaccines 2021, 9(3), 271;
Received: 24 February 2021 / Revised: 15 March 2021 / Accepted: 16 March 2021 / Published: 18 March 2021
(This article belongs to the Special Issue Mucosal Responses in the Context of Natural Immunity to HIV)
Worldwide, most Human Immunodeficiency Virus (HIV) infections are acquired through heterosexual intercourse, and in sub-Saharan Africa, 59% of new HIV infections affect women. Vaccines and microbicides hold promise for preventing the acquisition of HIV. To this end, the study of HIV highly exposed seronegative (HESN) female commercial sex workers (CSWs), who constitute a model of natural immunity to HIV, provides an exceptional opportunity to determine important clues for the development of preventive strategies. Studies using both female genital tract (FGT) and peripheral blood samples of HESN CSWs, have allowed identifying distinct features, notably low-inflammatory patterns associated with resistance to infection. How this seemingly regulated response is achieved at the initial site of HIV infection remains unknown. One hypothesis is that populations presenting regulatory profiles contribute to the orchestration of potent anti-viral and low-inflammatory responses at the initial site of HIV transmission. Here, we view to update our knowledge regarding this issue. View Full-Text
Keywords: natural immunity; HIV; highly exposed seronegative (HESN); regulatory cells natural immunity; HIV; highly exposed seronegative (HESN); regulatory cells
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MDPI and ACS Style

Blondin-Ladrie, L.; Aranguren, M.; Doyon-Laliberté, K.; Poudrier, J.; Roger, M. The Importance of Regulation in Natural Immunity to HIV. Vaccines 2021, 9, 271.

AMA Style

Blondin-Ladrie L, Aranguren M, Doyon-Laliberté K, Poudrier J, Roger M. The Importance of Regulation in Natural Immunity to HIV. Vaccines. 2021; 9(3):271.

Chicago/Turabian Style

Blondin-Ladrie, Laurence, Matheus Aranguren, Kim Doyon-Laliberté, Johanne Poudrier, and Michel Roger. 2021. "The Importance of Regulation in Natural Immunity to HIV" Vaccines 9, no. 3: 271.

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