Association between Elevated TGA-IgA Titers and Older Age at Diagnosis with Absence of HBV Seroconversion in Celiac Children
Abstract
:1. Introduction
2. Materials and Methods
Statistical Analysis
3. Results
3.1. Mean TGA-IgA and Serologic Response to the Vaccination
3.2. Clinical Presentation and Serologic Response to the Vaccination
3.3. Median Age and Serologic Response to the Vaccination
3.4. Regression Analysis on the Response to the Vaccine
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Group A (anti HBs Ab > 10 mIU/mL) | Group B (anti HBs Ab < 10 mIU/mL) | p | |
---|---|---|---|
Number | 56 | 40 | |
Female | 36 | 26 | |
Male | 20 | 14 | |
Median Age | 6.93 (IQR: 4.57–9.84) | 11.1 (IQR: 7.51–11.98) | <0.001 |
TGA-IgA mean | 3.10 ± 2.90 | 5.10 ± 4.26 | 0.012 |
TGA-IgA <10 ULN | 51 | 28 | |
TGA-IgA >10 ULN | 5 | 12 | |
Symptomatic children | 49 | 33 | n.s |
Asymptomatic children | 7 | 7 | n.s |
β | Std. Error | OR [95% CI] | p | |
---|---|---|---|---|
TGA titers (high vs. low) | −1.67 | 0.73 | 0.19 [0.04–0.81] | 0.023 |
Symptoms (yes vs. no) | −0.96 | 0.75 | 0.38 [0.09–1.70] | 0.20 |
Age (years) | −0.33 | 0.09 | 0.72 [0.60–0.86] | 0.0002 |
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Trovato, C.M.; Montuori, M.; Sansone, A.; Morelli, A.; Russo, G.; Pietropaoli, N.; Oliva, S. Association between Elevated TGA-IgA Titers and Older Age at Diagnosis with Absence of HBV Seroconversion in Celiac Children. Vaccines 2021, 9, 101. https://doi.org/10.3390/vaccines9020101
Trovato CM, Montuori M, Sansone A, Morelli A, Russo G, Pietropaoli N, Oliva S. Association between Elevated TGA-IgA Titers and Older Age at Diagnosis with Absence of HBV Seroconversion in Celiac Children. Vaccines. 2021; 9(2):101. https://doi.org/10.3390/vaccines9020101
Chicago/Turabian StyleTrovato, Chiara Maria, Monica Montuori, Andrea Sansone, Annalisa Morelli, Giusy Russo, Nicoletta Pietropaoli, and Salvatore Oliva. 2021. "Association between Elevated TGA-IgA Titers and Older Age at Diagnosis with Absence of HBV Seroconversion in Celiac Children" Vaccines 9, no. 2: 101. https://doi.org/10.3390/vaccines9020101