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Brief Report

Influenza Vaccination and Risk of SARS-CoV-2 Infection in a Cohort of Health Workers

1
Instituto de Salud Pública de Navarra–IdiSNA, 31003 Pamplona, Spain
2
CIBER Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain
3
Clinical Microbiology Department, Complejo Hospitalario de Navarra–IdiSNA, 31008 Pamplona, Spain
*
Author to whom correspondence should be addressed.
Vaccines 2020, 8(4), 611; https://doi.org/10.3390/vaccines8040611
Received: 25 September 2020 / Revised: 9 October 2020 / Accepted: 12 October 2020 / Published: 15 October 2020
Vaccines may induce positive non-specific immune responses to other pathogens. This study aims to evaluate if influenza vaccination in the 2019–2020 season had any effect on the risk of SARS-CoV-2 confirmed infection in a cohort of health workers. During the first SARS-CoV-2 epidemic wave in Spain, between March and May 2020, a cohort of 11,201 health workers was highly tested by RT-qPCR and/or rapid antibody test when the infection was suspected. Later in June, 8665 of them were tested for total antibodies in serum. A total of 890 (7.9%) health workers were laboratory-confirmed for SARS-CoV-2 infection by any type of test, while no case of influenza was detected. The adjusted odds ratio between 2019–2020 influenza vaccination and SARS-CoV-2 confirmed infection was the same (1.07; 95% CI, 0.92–1.24) in both comparisons of positive testers with all others (cohort design) and with negative testers (test-negative design). Among symptomatic patients tested by RT-qPCR, the comparison of positive cases and negative controls showed an adjusted odds ratio of 0.86 (95% CI, 0.68–1.08). These results suggest that influenza vaccination does not significantly modify the risk of SARS-CoV-2 infection. The development of specific vaccines against SARS-CoV-2 is urgent. View Full-Text
Keywords: SARS-CoV-2; COVID-19; influenza vaccination; health workers; pandemic SARS-CoV-2; COVID-19; influenza vaccination; health workers; pandemic
MDPI and ACS Style

Martínez-Baz, I.; Trobajo-Sanmartín, C.; Arregui, I.; Navascués, A.; Adelantado, M.; Indurain, J.; Fresán, U.; Ezpeleta, C.; Castilla, J. Influenza Vaccination and Risk of SARS-CoV-2 Infection in a Cohort of Health Workers. Vaccines 2020, 8, 611. https://doi.org/10.3390/vaccines8040611

AMA Style

Martínez-Baz I, Trobajo-Sanmartín C, Arregui I, Navascués A, Adelantado M, Indurain J, Fresán U, Ezpeleta C, Castilla J. Influenza Vaccination and Risk of SARS-CoV-2 Infection in a Cohort of Health Workers. Vaccines. 2020; 8(4):611. https://doi.org/10.3390/vaccines8040611

Chicago/Turabian Style

Martínez-Baz, Iván, Camino Trobajo-Sanmartín, Irati Arregui, Ana Navascués, Marta Adelantado, Juan Indurain, Ujué Fresán, Carmen Ezpeleta, and Jesús Castilla. 2020. "Influenza Vaccination and Risk of SARS-CoV-2 Infection in a Cohort of Health Workers" Vaccines 8, no. 4: 611. https://doi.org/10.3390/vaccines8040611

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