Resident Memory T Cells and Their Effect on Cancer
Abstract
1. Introduction
2. TRM Cells in Cancer
2.1. Function of TRM Cells in Cancer
2.2. Identification of TRM Cells in Patient Samples
2.3. Improving Vaccine Efficacy
2.4. Improving Adoptive T Cell Therapy
2.5. TRM Cell Clinical Trials
3. Future Directions
4. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Tumor Type | TRM Markers | No. of Samples/Patients | Reference |
---|---|---|---|
Ovarian Cancer | CD103 | 489 | [27] |
CD103 | 497 | [34] | |
CD103, CD3, TCRαβ, CD8αβ, CD4 | 186 | [84] | |
Cervical Cancer | CD103 | 460 | [11] |
Melanoma | CD69, CD103, TNFRSF18, CD8 | 44 | [23] |
CD8, CD103, CD69 | 18 | [85] | |
Lung Cancers | CD8, CD103, CD3 | 101 | [9] |
CD8, CD103 | 77 | [10] | |
CD8, CD103 | 510 | [86] | |
Pancreatic Cancer | CD8, CD103 | 136 | [87] |
Breast Cancer | CD8, CD103 | 424 | [8] |
CD8, T cell gene signatures | 989 | [88] |
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Craig, D.J.; Creeden, J.F.; Einloth, K.R.; Gillman, C.E.; Stanbery, L.; Hamouda, D.; Edelman, G.; Dworkin, L.; Nemunaitis, J.J. Resident Memory T Cells and Their Effect on Cancer. Vaccines 2020, 8, 562. https://doi.org/10.3390/vaccines8040562
Craig DJ, Creeden JF, Einloth KR, Gillman CE, Stanbery L, Hamouda D, Edelman G, Dworkin L, Nemunaitis JJ. Resident Memory T Cells and Their Effect on Cancer. Vaccines. 2020; 8(4):562. https://doi.org/10.3390/vaccines8040562
Chicago/Turabian StyleCraig, Daniel J., Justin F. Creeden, Katelyn R. Einloth, Cassidy E. Gillman, Laura Stanbery, Danae Hamouda, Gerald Edelman, Lance Dworkin, and John J. Nemunaitis. 2020. "Resident Memory T Cells and Their Effect on Cancer" Vaccines 8, no. 4: 562. https://doi.org/10.3390/vaccines8040562
APA StyleCraig, D. J., Creeden, J. F., Einloth, K. R., Gillman, C. E., Stanbery, L., Hamouda, D., Edelman, G., Dworkin, L., & Nemunaitis, J. J. (2020). Resident Memory T Cells and Their Effect on Cancer. Vaccines, 8(4), 562. https://doi.org/10.3390/vaccines8040562