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Review

Current State of Global African Swine Fever Vaccine Development under the Prevalence and Transmission of ASF in China

1
College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China
2
Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou 510642, China
3
Hog Production Division, Guangdong Wen2019s Foodstuffs Group Co, Ltd., Xinxing 527439, China
*
Author to whom correspondence should be addressed.
Vaccines 2020, 8(3), 531; https://doi.org/10.3390/vaccines8030531
Received: 24 August 2020 / Revised: 13 September 2020 / Accepted: 14 September 2020 / Published: 15 September 2020
(This article belongs to the Special Issue African Swine Fever Virus Prevention and Control)
African swine fever (ASF) is a highly lethal contagious disease of swine caused by African swine fever virus (ASFV). At present, it is listed as a notifiable disease reported to the World Organization for Animal Health (OIE) and a class one animal disease ruled by Chinese government. ASF has brought significant economic losses to the pig industry since its outbreak in China in August 2018. In this review, we recapitulated the epidemic situation of ASF in China as of July 2020 and analyzed the influencing factors during its transmission. Since the situation facing the prevention, control, and eradication of ASF in China is not optimistic, safe and effective vaccines are urgently needed. In light of the continuous development of ASF vaccines in the world, the current scenarios and evolving trends of ASF vaccines are emphatically analyzed in the latter part of the review. The latest research outcomes showed that attempts on ASF gene-deleted vaccines and virus-vectored vaccines have proven to provide complete homologous protection with promising efficacy. Moreover, gaps and future research directions of ASF vaccine are also discussed. View Full-Text
Keywords: African swine fever; ASFV; China; epidemic situation; vaccines; progress African swine fever; ASFV; China; epidemic situation; vaccines; progress
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MDPI and ACS Style

Wu, K.; Liu, J.; Wang, L.; Fan, S.; Li, Z.; Li, Y.; Yi, L.; Ding, H.; Zhao, M.; Chen, J. Current State of Global African Swine Fever Vaccine Development under the Prevalence and Transmission of ASF in China. Vaccines 2020, 8, 531. https://doi.org/10.3390/vaccines8030531

AMA Style

Wu K, Liu J, Wang L, Fan S, Li Z, Li Y, Yi L, Ding H, Zhao M, Chen J. Current State of Global African Swine Fever Vaccine Development under the Prevalence and Transmission of ASF in China. Vaccines. 2020; 8(3):531. https://doi.org/10.3390/vaccines8030531

Chicago/Turabian Style

Wu, Keke, Jiameng Liu, Lianxiang Wang, Shuangqi Fan, Zhaoyao Li, Yuwan Li, Lin Yi, Hongxing Ding, Mingqiu Zhao, and Jinding Chen. 2020. "Current State of Global African Swine Fever Vaccine Development under the Prevalence and Transmission of ASF in China" Vaccines 8, no. 3: 531. https://doi.org/10.3390/vaccines8030531

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