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Communication

Impact of Pre-Existing Immunity on Live Attenuated Influenza Vaccine-Induced Cross-Protective Immunity

1
Department of Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208-3479, USA
2
Immunotherapy, Inflammation and Cancer, Aragon Health Research Institute, Biomedical Research Centre of Aragon, 50009 Zaragoza, Spain
3
The School of Chemistry and Molecular Biosciences, The Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane 4072, Australia
*
Author to whom correspondence should be addressed.
Vaccines 2020, 8(3), 459; https://doi.org/10.3390/vaccines8030459
Received: 16 July 2020 / Revised: 12 August 2020 / Accepted: 14 August 2020 / Published: 20 August 2020
The efficacy of the intranasally (i.n.) delivered live attenuated influenza vaccine (LAIV) is variable and, in some seasons, suboptimal. In this study, we report that LAIV exhibits cross-protective efficacy in mice, potentially associated with cellular immunity as opposed to antigen-specific antibody responses. However, pre-exposure to the intramuscularly (i.m.) delivered inactivated influenza vaccine (IIV) severely impaired LAIV-induced cross-protection against heterologous challenge, potentially by inhibiting replication of LAIV. Our findings suggest that pre-existing immunity afforded by IIV suppresses cross-protective T cell immunogenicity of LAIV. View Full-Text
Keywords: influenza; pre-existing immunity; live attenuated influenza vaccine; inactivated influenza vaccine influenza; pre-existing immunity; live attenuated influenza vaccine; inactivated influenza vaccine
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MDPI and ACS Style

Roy, S.; Williams, C.M.; Pardo, J.; Wijesundara, D.K.; Furuya, Y. Impact of Pre-Existing Immunity on Live Attenuated Influenza Vaccine-Induced Cross-Protective Immunity. Vaccines 2020, 8, 459. https://doi.org/10.3390/vaccines8030459

AMA Style

Roy S, Williams CM, Pardo J, Wijesundara DK, Furuya Y. Impact of Pre-Existing Immunity on Live Attenuated Influenza Vaccine-Induced Cross-Protective Immunity. Vaccines. 2020; 8(3):459. https://doi.org/10.3390/vaccines8030459

Chicago/Turabian Style

Roy, Sreeja, Clare M. Williams, Julian Pardo, Danushka K. Wijesundara, and Yoichi Furuya. 2020. "Impact of Pre-Existing Immunity on Live Attenuated Influenza Vaccine-Induced Cross-Protective Immunity" Vaccines 8, no. 3: 459. https://doi.org/10.3390/vaccines8030459

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