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Review

Pneumococcal Vaccination for Children in Asian Countries: A Systematic Review of Economic Evaluation Studies

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Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Padjadjaran University, Bandung 40132, Indonesia
2
Center of Excellence in Higher Education for Pharmaceutical Care Innovation, Padjadjaran University, Bandung 40132, Indonesia
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Research Department of Practice and Policy, School of Pharmacy, University College London, London WC1N 1AX, UK
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Center for Health Technology Assessment, Universitas Padjadjaran, Bandung 40132, Indonesia
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Unit of Global Health, Department of Health Sciences, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, The Netherlands
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Unit of PharmacoTherapy, Epidemiology and Economics (PTE2), Department of Pharmacy, University of Groningen, 9713 AV Groningen, The Netherlands
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Department of Economics, Econometrics and Finance, Faculty of Economics and Business, University of Groningen, 9747 AE Groningen, The Netherlands
*
Author to whom correspondence should be addressed.
Vaccines 2020, 8(3), 426; https://doi.org/10.3390/vaccines8030426
Received: 1 July 2020 / Revised: 21 July 2020 / Accepted: 27 July 2020 / Published: 30 July 2020
Background: Evidence on costs and health benefits of pneumococcal conjugate vaccine (PCV) for children in Asian countries is limited but growing. As a region with a considerably high burden of pneumococcal disease, it is prominent to have a comprehensive overview on the cost-effectiveness of implementing and adopting a PCV vaccination program. Methods: We conducted a systematic review from Pubmed and Embase to identify economic evaluation studies of PCV for children in Asian countries up to May 2020. Data extraction included specific characteristics of the study, input parameters, cost elements, cost-effectiveness results, and key drivers of uncertainty. The Preferred Reporting Items for Systematic Reviews and Meta Analyses (PRISMA) statement was followed for this systematic review. The reporting quality of the included studies was evaluated using the Consolidated Health Economic Evaluation Reporting Standards (CHEERS) statement. Results: After the screening process on both the title and abstract and full text of 518 records, a total of 25 studies fulfilled the inclusion criteria, and were included in the review. The majority of included studies demonstrates that PCV for children is cost-effective in most of the Asian region, and even cost-saving in some countries. Most of the included studies implemented cost utility analysis (CUA) using either quality-adjusted life years (QALYs) or disability-adjusted life years (DALYs). Overall, the main drivers affecting the cost effectiveness were vaccine price, burden regarding pneumonia-related parameters, and the inclusion of herd effects. Conclusion: The children pneumococcal vaccination program appears to be a cost-effective intervention in Asia, and even cost-saving in certain conditions. Vaccine price, pneumonia-related disease burden, and the inclusion of the herd effect are observed as important key drivers in estimating cost-effectiveness in this region. Incorporating PCV in vaccination programs in this region was found to be highly favorable. View Full-Text
Keywords: Asia; cost analysis; cost-effectiveness; children; pneumococcal conjugate vaccine Asia; cost analysis; cost-effectiveness; children; pneumococcal conjugate vaccine
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MDPI and ACS Style

Zakiyah, N.; Insani, W.N.; Suwantika, A.A.; van der Schans, J.; Postma, M.J. Pneumococcal Vaccination for Children in Asian Countries: A Systematic Review of Economic Evaluation Studies. Vaccines 2020, 8, 426. https://doi.org/10.3390/vaccines8030426

AMA Style

Zakiyah N, Insani WN, Suwantika AA, van der Schans J, Postma MJ. Pneumococcal Vaccination for Children in Asian Countries: A Systematic Review of Economic Evaluation Studies. Vaccines. 2020; 8(3):426. https://doi.org/10.3390/vaccines8030426

Chicago/Turabian Style

Zakiyah, Neily; Insani, Widya N.; Suwantika, Auliya A.; van der Schans, Jurjen; Postma, Maarten J. 2020. "Pneumococcal Vaccination for Children in Asian Countries: A Systematic Review of Economic Evaluation Studies" Vaccines 8, no. 3: 426. https://doi.org/10.3390/vaccines8030426

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