Epidemiologic Profile of Type-Specific Human Papillomavirus Infection after Initiation of HPV Vaccination

Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences 1-757 Asahimachi-dori, Chuo-ward, Niigata 951-8510, Japan

Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan

Department of Preventive Medicine, Faculty of Medicine, Saga University, Saga 849-8501, Japan

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Departments of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan

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Department of Obstetrics and Gynecology, Yokohama City University School of Medicine, Yokohama 236-0004, Japan

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Division of Environmental Medicine and Population Sciences, Department of Social and Environmental Medicine, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan

Author to whom correspondence should be addressed.

Vaccines 2020, 8(3), 425; https://doi.org/10.3390/vaccines8030425

Received: 10 June 2020 / Revised: 22 July 2020 / Accepted: 23 July 2020 / Published: 29 July 2020

(This article belongs to the Special Issue Development of Cross-Protective Vaccines)

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Abstract

Organized human papillomavirus vaccination (OHPV) in Japan was introduced in 2010 for girls aged 12–16 years who were born in 1994 or later. The rate of OHPV coverage was 70–80%. However, after suspension of the government vaccination recommendation, the coverage dramatically decreased. We aim to investigate the change in prevalence of HPV infection after the initiation of HPV vaccination. We recruited females aged 20–21 years attending public cervical cancer screening from 2014 to 2017 fiscal years (April 2014 to March 2018). Residual Pap test specimens were collected for HPV testing. We compared the prevalence of HPV type-specific infection between women registered in 2014 (born in 1993–1994, including the pre-OHPV generation) and registered in 2015–2017 (born in 1994–1997, the OHPV generation). We collected 2379 specimens. The vaccination coverage figures were 30.7%, 86.6%, 88.4% and 93.7% (p < 0.01) from 2014 to 2017, respectively. The prevalence of HPV16/18 infection significantly decreased from 1.3% in 2014 to 0% in 2017 (p = 0.02). The three most prevalent types were HPV52, 16 and 56 in 2014, and HPV52, 58 and 56 in 2015–2017, respectively. HPV16 and 33 infection rates decreased. On the other hand, the HPV58 infection rate was obviously increased after OHPV from 0.3% to 2.1%. Our study demonstrates that the prevalence of HPV16/18 infection dramatically decreased and the profile of type-specific HPV infection was changed after OHPV. View Full-Text

Keywords: HPV vaccine; HPV infection; cross-protection; type replacement

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MDPI and ACS Style

Sekine, M.; Yamaguchi, M.; Kudo, R.; J. B. Hanley, S.; Hara, M.; Adachi, S.; Ueda, Y.; Miyagi, E.; Ikeda, S.; Yagi, A.; Enomoto, T. Epidemiologic Profile of Type-Specific Human Papillomavirus Infection after Initiation of HPV Vaccination. Vaccines 2020, 8, 425. https://doi.org/10.3390/vaccines8030425

AMA Style

Sekine M, Yamaguchi M, Kudo R, J. B. Hanley S, Hara M, Adachi S, Ueda Y, Miyagi E, Ikeda S, Yagi A, Enomoto T. Epidemiologic Profile of Type-Specific Human Papillomavirus Infection after Initiation of HPV Vaccination. Vaccines. 2020; 8(3):425. https://doi.org/10.3390/vaccines8030425

Chicago/Turabian Style

Sekine, Masayuki, Manako Yamaguchi, Risa Kudo, Sharon J. B. Hanley, Megumi Hara, Sosuke Adachi, Yutaka Ueda, Etsuko Miyagi, Sayaka Ikeda, Asami Yagi, and Takayuki Enomoto. 2020. "Epidemiologic Profile of Type-Specific Human Papillomavirus Infection after Initiation of HPV Vaccination" Vaccines 8, no. 3: 425. https://doi.org/10.3390/vaccines8030425

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Epidemiologic Profile of Type-Specific Human Papillomavirus Infection after Initiation of HPV Vaccination

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