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Open AccessBrief Report

Prospects of Replication-Deficient Adenovirus Based Vaccine Development against SARS-CoV-2

Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via F. Marzolo 5, 35131 Padova, Italy
Chair of Drug and Cosmetics Biotechnology, Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, Poland
Department of Virology, National Institute of Public Health—National Institute of Hygiene, Chocimska 24, 00-791 Warsaw, Poland
Clinical Science, Targovax Oy, Saukonpaadenranta 2, 00180 Helsinki, Finland
Authors to whom correspondence should be addressed.
Vaccines 2020, 8(2), 293;
Received: 1 May 2020 / Revised: 29 May 2020 / Accepted: 6 June 2020 / Published: 10 June 2020
The current appearance of the new SARS coronavirus 2 (SARS-CoV-2) and it quickly spreading across the world poses a global health emergency. The serious outbreak position is affecting people worldwide and requires rapid measures to be taken by healthcare systems and governments. Vaccinations represent the most effective strategy to prevent the epidemic of the virus and to further reduce morbidity and mortality with long-lasting effects. Nevertheless, currently there are no licensed vaccines for the novel coronaviruses. Researchers and clinicians from all over the world are advancing the development of a vaccine against novel human SARS-CoV-2 using various approaches. Herein, we aim to present and discuss the progress and prospects in the field of vaccine research towards SARS-CoV-2 using adenovirus (AdV) replication deficient-based strategies, with a comprehension that may support research and combat this recent world health emergency. View Full-Text
Keywords: SARS-CoV-2; vaccine; adjuvant; adenovirus; COVID-19 SARS-CoV-2; vaccine; adjuvant; adenovirus; COVID-19
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Garofalo, M.; Staniszewska, M.; Salmaso, S.; Caliceti, P.; Pancer, K.W.; Wieczorek, M.; Kuryk, L. Prospects of Replication-Deficient Adenovirus Based Vaccine Development against SARS-CoV-2. Vaccines 2020, 8, 293.

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