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Vaccines
Volume 8
Issue 2
10.3390/vaccines8020202
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Article

CD8+ Tumour-Infiltrating Lymphocytes and Tumour Microenvironment Immune Types as Biomarkers for Immunotherapy in Sinonasal Intestinal-Type Adenocarcinoma

by
Rocío García-Marín
1,†,
Sara Reda
2,†,
Cristina Riobello
1,
Virginia N. Cabal
1,
Laura Suárez-Fernández
1,
Blanca Vivanco
3,
Fernando López
2,
José L. Llorente
2 and
Mario A. Hermsen
1,*
1
Department Head and Neck Oncology, Instituto de Investigación Sanitaria del Principado de Asturias, 33011 Oviedo, Spain
2
Department Otolaryngology, Hospital Universitario Central de Asturias, 33011 Oviedo, Spain
3
Department Pathology, Hospital Universitario Central de Asturias, 33011 Oviedo, Spain
*
Author to whom correspondence should be addressed.
†
Contributed equally.
Vaccines 2020, 8(2), 202; https://doi.org/10.3390/vaccines8020202
Submission received: 6 April 2020 / Revised: 22 April 2020 / Accepted: 26 April 2020 / Published: 28 April 2020
(This article belongs to the Special Issue Cancer Immunotherapy: Advances and Future Prospects)
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Abstract

Background. Intestinal-type adenocarcinoma (ITAC) is a rare tumour occurring in the ethmoid sinus. Recent years have brought advances in endoscopic surgery and precision radiotherapy; however, five-year overall survival has not improved and remains at 35–80%, depending on tumour stage and histology. Therefore, there is a need for new therapeutic options. Methods. We evaluated CD8+ tumour-infiltrating lymphocytes (TILs) and tumour microenvironment immune type (TMIT, combining CD8+ TILs and PD-L1) as predictive biomarkers for immunotherapy in a series of 133 ITAC. All results were correlated to clinical and follow-up data. Results. The presence of intratumoural CD8+ TILs was low in 57% of cases and high in 8% of cases. Tumoural PD-L1 positivity was observed in 26% of cases. CD8+ TILs and TMIT correlated with the histological subtype of ITAC and with better overall survival. The presence of stromal PD-L1-positive macrophages was related to intratumoural CD8+ TILs. PD-L1 expression on tumour cells or macrophages did not show prognostic value. Conclusions. TMIT classification did not have additional prognostic value over CD8+ TILs alone. The modest percentage of CD8high/PD-L1pos cases indicates that ITAC is a lowly immunogenic tumour type. Nevertheless, a proportion of ITAC, especially the papillary and colonic subtypes, could benefit from therapy with immune checkpoint inhibitors.
Keywords: sinonasal cancer; intestinal-type adenocarcinoma; CD8+ TILs; tumour microenvironment immune type; immunotherapy sinonasal cancer; intestinal-type adenocarcinoma; CD8+ TILs; tumour microenvironment immune type; immunotherapy

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MDPI and ACS Style

García-Marín, R.; Reda, S.; Riobello, C.; Cabal, V.N.; Suárez-Fernández, L.; Vivanco, B.; López, F.; Llorente, J.L.; Hermsen, M.A. CD8+ Tumour-Infiltrating Lymphocytes and Tumour Microenvironment Immune Types as Biomarkers for Immunotherapy in Sinonasal Intestinal-Type Adenocarcinoma. Vaccines 2020, 8, 202. https://doi.org/10.3390/vaccines8020202

AMA Style

García-Marín R, Reda S, Riobello C, Cabal VN, Suárez-Fernández L, Vivanco B, López F, Llorente JL, Hermsen MA. CD8+ Tumour-Infiltrating Lymphocytes and Tumour Microenvironment Immune Types as Biomarkers for Immunotherapy in Sinonasal Intestinal-Type Adenocarcinoma. Vaccines. 2020; 8(2):202. https://doi.org/10.3390/vaccines8020202

Chicago/Turabian Style

García-Marín, Rocío, Sara Reda, Cristina Riobello, Virginia N. Cabal, Laura Suárez-Fernández, Blanca Vivanco, Fernando López, José L. Llorente, and Mario A. Hermsen. 2020. "CD8+ Tumour-Infiltrating Lymphocytes and Tumour Microenvironment Immune Types as Biomarkers for Immunotherapy in Sinonasal Intestinal-Type Adenocarcinoma" Vaccines 8, no. 2: 202. https://doi.org/10.3390/vaccines8020202

APA Style

García-Marín, R., Reda, S., Riobello, C., Cabal, V. N., Suárez-Fernández, L., Vivanco, B., López, F., Llorente, J. L., & Hermsen, M. A. (2020). CD8+ Tumour-Infiltrating Lymphocytes and Tumour Microenvironment Immune Types as Biomarkers for Immunotherapy in Sinonasal Intestinal-Type Adenocarcinoma. Vaccines, 8(2), 202. https://doi.org/10.3390/vaccines8020202

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