Co-Administration of Injected and Oral Vaccine Candidates Elicits Improved Immune Responses over Either Route Alone
Abstract
:1. Introduction
2. Materials and Methods
2.1. Maize Material
2.2. Seed Processing
2.3. Vaccine Preparation
2.4. HBsAg Mouse Vaccine Trial
2.5. HBsAg and Ag2 Quantification
2.6. Hepatitis B Vaccine Mouse Study
2.7. Anti-HBsAg Antibody Detection in Mice
2.8. Coccidioides Vaccine Mouse Study
2.9. Analysis of CFUs and Weight Change
3. Results
3.1. HBsAg Vaccine Production
3.2. Mucosal Response
3.3. Serum Response
3.4. Coccidioides Mouse Study
4. Discussion
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Hayden, C.A.; Landrock, D.; Hung, C.Y.; Ostroff, G.; Fake, G.M.; Walker, J.H.; Kier, A.; Howard, J.A. Co-Administration of Injected and Oral Vaccine Candidates Elicits Improved Immune Responses over Either Route Alone. Vaccines 2020, 8, 37. https://doi.org/10.3390/vaccines8010037
Hayden CA, Landrock D, Hung CY, Ostroff G, Fake GM, Walker JH, Kier A, Howard JA. Co-Administration of Injected and Oral Vaccine Candidates Elicits Improved Immune Responses over Either Route Alone. Vaccines. 2020; 8(1):37. https://doi.org/10.3390/vaccines8010037
Chicago/Turabian StyleHayden, Celine A., Danilo Landrock, Chiung Yu Hung, Gary Ostroff, Gina M. Fake, John H. Walker, Ann Kier, and John A. Howard. 2020. "Co-Administration of Injected and Oral Vaccine Candidates Elicits Improved Immune Responses over Either Route Alone" Vaccines 8, no. 1: 37. https://doi.org/10.3390/vaccines8010037