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Open AccessArticle

The Unknown Health Burden of Herpes Zoster Hospitalizations: The Effect on Chronic Disease Course in Adult Patients ≥50 Years

1
Department of Health Sciences, University of Genoa, Via Antonio Pastore 1, 16132 Genoa, Italy
2
A.Li.Sa., Liguria Health Authority, Piazza della Vittoria 15, 16121 Genoa, Italy
3
Hygiene Unit, San Martino Polyclinic Hospital, Largo Rosanna Benzi 10, 16132 Genoa, Italy
4
Liguria Digitale S.p.A., Via Enrico Melen 77, 16152 Genoa, Italy
*
Author to whom correspondence should be addressed.
Vaccines 2020, 8(1), 20; https://doi.org/10.3390/vaccines8010020
Received: 27 December 2019 / Revised: 8 January 2020 / Accepted: 8 January 2020 / Published: 10 January 2020
(This article belongs to the Special Issue Vaccination and Vaccine Effectiveness)
The effect of severe Herpes Zoster (HZ) on chronic diseases is a component of the real burden of this vaccine-preventable disease that is not commonly considered. A retrospective cohort study was conducted to assess the health burden of severe HZ in adults ≥50 years residing in Liguria Region from 2015 to 2017. Subjects hospitalized with and without HZ were matched (1:6 ratio). 437 subjects in the HZ cohort and 2622 subjects in the non-HZ cohort were enrolled. Previous immunodeficiency, autoimmune, and rare diseases are identified as main chronic conditions related to HZ hospitalization. Higher incidences of autoimmune (1.4% vs. 0.22%, p = 0.002) and gastrointestinal (7.04% vs. 3.62%, p = 0.015) diseases after hospitalization were observed in the HZ cohort compared to the non-HZ cohort. Significantly higher incidences were found after hospitalization versus the previous period for cardiovascular diseases (11.17% vs. 2.09%, p < 0.001), cerebral vasculopathy (6.13% vs. 0.60%, p < 0.001), non-arrhythmic myocardiopathy (4.31% vs. 0.59%, p = 0.002), and neuropathy (2.62% vs. 0.56%, p = 0.033). The HZ cohort showed a relative risk 10-fold higher for cerebral vasculopathy, 5-fold higher for cardiovascular diseases, and 7-fold higher for non-arrhythmic myocardiopathy. HZ causes a substantial impact on the chronic conditions. These data could suggest an implementation of HZ vaccination programs in the elderly and in high-risk groups. View Full-Text
Keywords: Herpes Zoster; hospitalizations; chronic diseases; risk factors; high-risk groups; elderly; cerebral vasculopathy; readmissions and drug therapy Herpes Zoster; hospitalizations; chronic diseases; risk factors; high-risk groups; elderly; cerebral vasculopathy; readmissions and drug therapy
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Piazza, M.F.; Paganino, C.; Amicizia, D.; Trucchi, C.; Orsi, A.; Astengo, M.; Romairone, P.; Simonetti, S.; Icardi, G.; Ansaldi, F. The Unknown Health Burden of Herpes Zoster Hospitalizations: The Effect on Chronic Disease Course in Adult Patients ≥50 Years. Vaccines 2020, 8, 20.

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