SLAM Family Receptor Signaling in Viral Infections: HIV and Beyond
1
Department of Microbiology and Molecular Genetics, College of Osteopathic Medicine, Michigan State University, East Lansing, MI 48824, USA
2
Department of Pediatrics, College of Osteopathic Medicine, Michigan State University, East Lansing, MI 48824, USA
*
Author to whom correspondence should be addressed.
Vaccines 2019, 7(4), 184; https://doi.org/10.3390/vaccines7040184
Received: 15 October 2019
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Revised: 4 November 2019
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Accepted: 13 November 2019
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Published: 16 November 2019
(This article belongs to the Special Issue HIV Vaccine)
The signaling lymphocytic activation molecule (SLAM) family of receptors are expressed on the majority of immune cells. These receptors often serve as self-ligands, and play important roles in cellular communication and adhesion, thus modulating immune responses. SLAM family receptor signaling is differentially regulated in various immune cell types, with responses generally being determined by the presence or absence of two SLAM family adaptor proteins—Ewing’s sarcoma-associated transcript 2 (EAT-2) and SLAM-associated adaptor protein (SAP). In addition to serving as direct regulators of the immune system, certain SLAM family members have also been identified as direct targets for specific microbes and viruses. Here, we will discuss the known roles for these receptors in the setting of viral infection, with special emphasis placed on HIV infection. Because HIV causes such complex dysregulation of the immune system, studies of the roles for SLAM family receptors in this context are particularly exciting.
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Keywords:
HIV; SLAM; SAP; EAT-2; SLAMF7; SLAMF6; innate immunity; adaptive immunity; immune-modulation
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MDPI and ACS Style
O’Connell, P.; Amalfitano, A.; Aldhamen, Y.A. SLAM Family Receptor Signaling in Viral Infections: HIV and Beyond. Vaccines 2019, 7, 184. https://doi.org/10.3390/vaccines7040184
AMA Style
O’Connell P, Amalfitano A, Aldhamen YA. SLAM Family Receptor Signaling in Viral Infections: HIV and Beyond. Vaccines. 2019; 7(4):184. https://doi.org/10.3390/vaccines7040184
Chicago/Turabian StyleO’Connell, Patrick, Andrea Amalfitano, and Yasser A. Aldhamen. 2019. "SLAM Family Receptor Signaling in Viral Infections: HIV and Beyond" Vaccines 7, no. 4: 184. https://doi.org/10.3390/vaccines7040184
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