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Vaccine Vectors Harnessing the Power of Cytomegaloviruses

Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany
German Centre for Infection Research (DZIF), partner site Hannover/Braunschweig, 38124 Braunschweig, Germany
Centre for Individualised Infection Medicine (CiiM), a joint venture of Helmholtz Centre for Infection Research and Hannover Medical School, 30625 Hannover, Germany
Author to whom correspondence should be addressed.
Current address: Department of Dermatology, University of Zurich Hospital, University of Zurich, 8091 Zurich, Switzerland.
Vaccines 2019, 7(4), 152;
Received: 20 July 2019 / Revised: 11 October 2019 / Accepted: 14 October 2019 / Published: 17 October 2019
(This article belongs to the Special Issue Cytomegalovirus Infection and Vaccine Development)
Cytomegalovirus (CMV) species have been gaining attention as experimental vaccine vectors inducing cellular immune responses of unparalleled strength and protection. This review outline the strengths and the restrictions of CMV-based vectors, in light of the known aspects of CMV infection, pathogenicity and immunity. We discuss aspects to be considered when optimizing CMV based vaccines, including the innate immune response, the adaptive humoral immunity and the T-cell responses. We also discuss the antigenic epitopes presented by unconventional major histocompatibility complex (MHC) molecules in some CMV delivery systems and considerations about routes for delivery for the induction of systemic or mucosal immune responses. With the first clinical trials initiating, CMV-based vaccine vectors are entering a mature phase of development. This impetus needs to be maintained by scientific advances that feed the progress of this technological platform. View Full-Text
Keywords: cytomegalovirus; vaccine vector; memory inflation; immunotherapy; immunization; vaccine development cytomegalovirus; vaccine vector; memory inflation; immunotherapy; immunization; vaccine development
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Ynga-Durand, M.A.; Dekhtiarenko, I.; Cicin-Sain, L. Vaccine Vectors Harnessing the Power of Cytomegaloviruses. Vaccines 2019, 7, 152.

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