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Open AccessArticle

Factors Influencing Persistence of Diphtheria Immunity and Immune Response to a Booster Dose in Healthy Slovak Adults

1
Preventive Medicine, Third Faculty of Medicine, Charles University in Prague, 100 00 Prague, Czech Republic
2
Faculty of Healthcare, Alexander Dubček University of Trenčín, 911 50 Trenčín, Slovakia
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Faculty of Pharmacy, Comenius University in Bratislava, 832 32 Bratislava, Slovakia
4
Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, 036 01 Martin, Slovakia
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Faculty of Public Health, Slovak Medical University in Bratislava, 831 01 Bratislava, Slovakia
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Laboratory for Atherosclerosis Research, Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech Republic
*
Author to whom correspondence should be addressed.
Vaccines 2019, 7(4), 139; https://doi.org/10.3390/vaccines7040139
Received: 31 August 2019 / Revised: 20 September 2019 / Accepted: 1 October 2019 / Published: 7 October 2019
(This article belongs to the Section Vaccines against Infectious Diseases)
We assessed the long-term persistence of humoral immunity against diphtheria in adults with childhood vaccination and the immunogenicity of a booster dose considering demographic, behavioural and vaccinating factors. We conducted a trial in 200 healthy Slovak adults aged 24–65 years, immunised against diphtheria in childhood and against tetanus at regular 10–15 year intervals, and receiving a dose of a tetanus-diphtheria toxoid vaccine. The response was determined by ELISA antibody concentrations of paired sera before and at 4 weeks post-vaccination. A seroprotection rate of 21% (95% confidence interval, CI 15.6–27.3%) was found in adults up to 59 years since the last vaccination with seroprotective levels of antibodies against diphtheria ≥0.1 IU/mL and a geometric mean concentration of 0.05 IU/mL. Conversely, seropositive levels ≥0.01 IU/mL were observed in 98% of adults (95% CI 95–99.5%). Booster-induced seroprotection was achieved in 78% of adults (95% CI 71.6–83.5%) clearly depending on pre-booster antibody levels correlating with age and time since the last vaccination. Moreover, only 54.2% of smokers and 53.3% of patients on statins exhibited seroprotection. Booster vaccination against diphtheria was unable to confer seroprotection in all recipients of only childhood vaccination. View Full-Text
Keywords: diphtheria vaccination; seroprotection rate; smoking; statins; pre-vaccination levels; immunity persistence diphtheria vaccination; seroprotection rate; smoking; statins; pre-vaccination levels; immunity persistence
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MDPI and ACS Style

Petráš, M.; Oleár, V.; Molitorisová, M.; Dáňová, J.; Čelko, A.M.; Nováková, E.; Štefkovičová, M.; Krištúfková, Z.; Malinová, J.; Králová Lesná, I. Factors Influencing Persistence of Diphtheria Immunity and Immune Response to a Booster Dose in Healthy Slovak Adults. Vaccines 2019, 7, 139. https://doi.org/10.3390/vaccines7040139

AMA Style

Petráš M, Oleár V, Molitorisová M, Dáňová J, Čelko AM, Nováková E, Štefkovičová M, Krištúfková Z, Malinová J, Králová Lesná I. Factors Influencing Persistence of Diphtheria Immunity and Immune Response to a Booster Dose in Healthy Slovak Adults. Vaccines. 2019; 7(4):139. https://doi.org/10.3390/vaccines7040139

Chicago/Turabian Style

Petráš, Marek; Oleár, Vladimir; Molitorisová, Milica; Dáňová, Jana; Čelko, Alexander M.; Nováková, Elena; Štefkovičová, Mária; Krištúfková, Zuzana; Malinová, Jana; Králová Lesná, Ivana. 2019. "Factors Influencing Persistence of Diphtheria Immunity and Immune Response to a Booster Dose in Healthy Slovak Adults" Vaccines 7, no. 4: 139. https://doi.org/10.3390/vaccines7040139

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