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Vaccines 2018, 6(3), 49; https://doi.org/10.3390/vaccines6030049

Contribution of Host Defence Proteins and Peptides to Host-Microbiota Interactions in Chronic Inflammatory Lung Diseases

1
Department of Pulmonology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands
2
Department of Pediatric Pulmonology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht 3508 AB, The Netherlands
3
Regenerative Medicine Center, University Medical Center Utrecht, Utrecht 3508 AB, The Netherlands
4
Research Group Microbiology and Systems Biology, TNO (The Netherlands Organization for Applied Scientific Research), Zeist 3704 HE, The Netherlands
5
Department of Preventive Dentistry, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam, Amsterdam 1008 AA, The Netherlands
6
Emulate Inc., Boston, MA 02210, USA
*
Author to whom correspondence should be addressed.
Received: 6 July 2018 / Revised: 23 July 2018 / Accepted: 25 July 2018 / Published: 28 July 2018
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Abstract

The respiratory tract harbours a variety of microorganisms, collectively called the respiratory microbiota. Over the past few years, alterations in respiratory and gut microbiota composition have been associated with chronic inflammatory diseases of the lungs. How these changes influence disease development and progression is an active field of investigation. Identifying and understanding host-microbiota interactions and factors contributing to these interactions could promote the development of novel therapeutic strategies aimed at restoring host-microbiota homeostasis. In this review, we discuss recent literature on host-microbiota interactions in the respiratory tract, with a specific focus on the influence of endogenous host defence peptides and proteins (HDPs) on the composition of microbiota populations in vivo and explore possible HDPs-related therapeutic approaches targeting microbiota dysbiosis in chronic inflammatory lung diseases. View Full-Text
Keywords: chronic inflammatory lung diseases; COPD; Asthma; cystic fibrosis; microbiota; host defence peptides; host-microbiota interactions chronic inflammatory lung diseases; COPD; Asthma; cystic fibrosis; microbiota; host defence peptides; host-microbiota interactions
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van der Does, A.M.; Amatngalim, G.D.; Keijser, B.; Hiemstra, P.S.; Villenave, R. Contribution of Host Defence Proteins and Peptides to Host-Microbiota Interactions in Chronic Inflammatory Lung Diseases. Vaccines 2018, 6, 49.

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