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Repurposing Plant Virus Nanoparticles

Department of Food Sciences, Cornell University, Ithaca, NY 14886, USA
Vaccines 2018, 6(1), 11; https://doi.org/10.3390/vaccines6010011
Received: 23 December 2017 / Revised: 26 January 2018 / Accepted: 2 February 2018 / Published: 14 February 2018
Plants have been explored for many years as inexpensive and versatile platforms for the generation of vaccines and other biopharmaceuticals. Plant viruses have also been engineered to either express subunit vaccines or act as epitope presentation systems. Both icosahedral and helical, filamentous-shaped plant viruses have been used for these purposes. More recently, plant viruses have been utilized as nanoparticles to transport drugs and active molecules into cancer cells. The following review describes the use of both icosahedral and helical plant viruses in a variety of new functions against cancer. The review illustrates the breadth of variation among different plant virus nanoparticles and how this impacts the immune response. View Full-Text
Keywords: plant virus; nanoparticle; epitope; vaccine; cancer; imaging plant virus; nanoparticle; epitope; vaccine; cancer; imaging
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Hefferon, K.L. Repurposing Plant Virus Nanoparticles. Vaccines 2018, 6, 11.

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