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Meningococcal Vaccines: Current Status and Emerging Strategies

Department of Chemistry, Morgan State University, Baltimore, MD 21251, USA
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Vaccines 2018, 6(1), 12; https://doi.org/10.3390/vaccines6010012
Received: 30 January 2018 / Revised: 21 February 2018 / Accepted: 23 February 2018 / Published: 25 February 2018
(This article belongs to the Collection Vaccines against Chronic and Persistent Bacterial Infections)
Neisseria meningitidis causes most cases of bacterial meningitis. Meningococcal meningitis is a public health burden to both developed and developing countries throughout the world. There are a number of vaccines (polysaccharide-based, glycoconjugate, protein-based and combined conjugate vaccines) that are approved to target five of the six disease-causing serogroups of the pathogen. Immunization strategies have been effective at helping to decrease the global incidence of meningococcal meningitis. Researchers continue to enhance these efforts through discovery of new antigen targets that may lead to a broadly protective vaccine and development of new methods of homogenous vaccine production. This review describes current meningococcal vaccines and discusses some recent research discoveries that may transform vaccine development against N. meningitidis in the future. View Full-Text
Keywords: Neisseria meningitidis; glycoconjugate vaccines; protein-based vaccines; vaccine development Neisseria meningitidis; glycoconjugate vaccines; protein-based vaccines; vaccine development
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McCarthy, P.C.; Sharyan, A.; Sheikhi Moghaddam, L. Meningococcal Vaccines: Current Status and Emerging Strategies. Vaccines 2018, 6, 12.

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