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Vaccines 2015, 3(3), 544-555;

Systems Biology Approach for Cancer Vaccine Development and Evaluation

Laboratory of Molecular Biology and Viral Oncology, Department of Experimental Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori, "Fondazione Pascale" - IRCCS, Naples 80131, Italy
Author to whom correspondence should be addressed.
Academic Editor: Mary Lenora (Nora) Disis
Received: 26 May 2015 / Revised: 2 July 2015 / Accepted: 3 July 2015 / Published: 14 July 2015
(This article belongs to the Special Issue Cancer Vaccines)
Full-Text   |   PDF [129 KB, uploaded 14 July 2015]   |  


Therapeutic cancer vaccines do not hold promise yet as an effective anti-cancer treatment. Lack of efficacy or poor clinical outcomes are due to several antigenic and immunological aspects that need to be addressed in order to reverse such trends and significantly improve cancer vaccines’ efficacy. The newly developed high throughput technologies and computational tools are instrumental to this aim allowing the identification of more specific antigens and the comprehensive analysis of the innate and adaptive immunities. Here, we review the potentiality of systems biology in providing novel insights in the mechanisms of the action of vaccines to improve their design and effectiveness. View Full-Text
Keywords: systems vaccinology; cancer vaccine; cancer immunotherapy systems vaccinology; cancer vaccine; cancer immunotherapy

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Circelli, L.; Petrizzo, A.; Tagliamonte, M.; Tornesello, M.L.; Buonaguro, F.M.; Buonaguro, L. Systems Biology Approach for Cancer Vaccine Development and Evaluation. Vaccines 2015, 3, 544-555.

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