COVID-19 Vaccination Uptake and Effectiveness for Hospitalized Cases Among Healthcare Workers in Tertiary Hospital
Abstract
1. Introduction
2. Materials and Methods
2.1. Study Design and Setting
2.2. Participants
“Suspected cases” are patients seeking medical care as suspects (with symptoms or after contact with a confirmed case”. “Confirmed cases are individuals with a quantitative reverse transcription polymerase chain reaction test (RT-PCR) positive for SARS-CoV-2”.[30]
2.3. Variables
2.4. Data Sources and Measurement
2.5. Bias
2.6. Sample Size
2.7. Statistical Methods and Analysis
3. Results
3.1. Distribution of COVID-19 Cases Across Eight Epidemiological Waves
3.2. Sociodemographic Characteristics of Patients with and Without COVID-19
3.3. Frequency of Symptoms and Underlying Comorbidities in Confirmed COVID-19 Patients
3.4. Immunization Scheme Across Vaccine Doses
3.5. Sociodemographic and Clinical Characteristics of Hospitalized COVID-19 Patients
3.6. Multivariable Analysis of Sociodemographic Characteristics and Severity of COVID-19
4. Discussion
5. Limitations
6. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Wave or Period | COVID-19 | |||
---|---|---|---|---|
Negative n = 4211 n (%) | Positive n = 2838 n (%) | Total n = 7049 n (%) | Positivity Rate (%) | |
Wave 1 (15 March to 29 September 2020) | 561 (13.32) | 270 (9.51) | 831 (11.79) | 32.49 |
Wave 2 (30 September 2020 to 15 April 2021) | 824 (19.57) | 415 (14.62) | 1239 (17.58) | 33.49 |
Wave 3 (16 April to 21 October 2021) | 407 (9.67) | 127 (4.47) | 534 (7.58) | 23.78 |
Wave 4 (22 October 2021 to 4 March 2022) | 684 (16.24) | 664 (23.40) | 1348 (19.12) | 49.26 |
Wave 5 (5 March to 19 August 2022) | 584 (13.87) | 777 (27.38) | 1361 (19.31) | 57.09 |
Wave 6 (20 August 2022 to 4 February 2023) | 238 (5.65) | 187 (6.59) | 425 (6.03) | 44.00 |
Wave 7 (5 February to 13 May 2023) | 119 (2.83) | 76 (2.68) | 195 (2.77) | 38.97 |
Post-COVID-19 Emergency (14 May 2023 to 20 May 2024) | 794 (18.86) | 322 (11.35) | 1116 (15.83) | 28.85 |
Total | 4211 | 2838 | 7049 | 40.26 |
Variable | COVID-19 | Total n = 7049 n (%) | p Value | |
---|---|---|---|---|
Negative n = 4211 n (%) | Positive n = 2838 n (%) | |||
Sex | ||||
Female | 2756 (65.45) | 1775 (62.54) | 4531 (64.28) | 0.013 |
Male | 1455 (34.55) | 1063 (37.46) | 2518 (35.72) | |
Age group | ||||
18 to 29 | 1003 (23.82) | 611 (21.53) | 1614 (22.90) | <0.001 |
30 to 39 | 1198 (28.45) | 721 (25.41) | 1919 (27.22) | |
40 to 49 | 1177 (27.95) | 816 (28.75) | 1993 (28.27) | |
50 to 59 | 691 (16.41) | 531 (18.71) | 1222 (17.34) | |
60 to 69 | 132 (3.13) | 137 (4.83) | 269 (3.82) | |
70 years | 10 (0.24) | 22 (0.78) | 32 (0.45) | |
Occupation | ||||
Nurse | 1488 (35.34) | 973 (34.30) | 2461 (34.92) | 0.003 |
Medical resident | 438 (10.40) | 268 (9.45) | 706 (10.02 | |
Medical student | 147 (3.49) | 68 (2.40) | 215(3.05) | |
Medical staff | 311 (7.39) | 245 (8.64) | 556 (7.89) | |
Administrative | 1154 (27.40) | 764 (26.93) | 1918 (27.21) | |
General services | 248 (5.89) | 179 (6.31) | 427 (6.06) | |
Paramedics | 300 (7.12) | 260 (9.16) | 560 (7.95) | |
Researchers | 125 (2.97) | 80 (2.82) | 205 (2.91) | |
Total | ||||
Clinical and epidemiological characteristics | ||||
Smoking | 303 (7.19) | 163 (5.74) | 466 (6.61) | 0.071 |
Signs and symptoms * | ||||
Cough | 1796 (42.65) | 1936 (68.22) | 3732 (52.94) | <0.001 |
Rhinorrhea | 1391 (33.03) | 1257 (44.29) | 2648 (37.57) | <0.001 |
Chills | 1244 (29.54) | 1231 (43.38) | 2475 (35.11) | <0.001 |
Fever | 922 (21.90) | 1043 (36.75) | 1965 (27.88) | <0.001 |
Myalgia | 964 (22.89) | 955 (33.65) | 1919 (27.22) | <0.001 |
Generalized Attack | 753 (17.88) | 713 (25.12) | 1466 (20.80) | <0.001 |
Pharyngodynia | 883 (20.97) | 669 (23.57) | 1552 (22.02) | 0.011 |
Arthralgia | 724 (17.19) | 707 (24.91) | 1431 (20.30) | <0.001 |
Diarrhea | 794 (18.86) | 470 (16.56) | 1264 (17.93) | 0.014 |
Alertness | 684 (16.24) | 541 (19.06) | 1225 (17.38) | 0.002 |
Chest Pain | 638 (15.15) | 556 (19.59) | 1194 (16.94) | <0.001 |
Abdominal Pain | 517 (12.28) | 321 (11.31) | 838 (11.89) | 0.219 |
Dyspnea | 335 (7.96) | 256 (9.02) | 591 (8.38) | 0.114 |
Dysphonia | 229 (5.44) | 145 (5.11) | 374 (5.31) | 0.546 |
Vomiting | 201 (4.77) | 120 (4.23) | 321 (4.55) | 0.282 |
Dysgeusia | 94 (2.23) | 138 (4.86) | 232 (3.29) | <0.001 |
Comorbidities * | ||||
Obesity | 736 (17.48) | 483 (17.02) | 1219 (17.29) | 0.617 |
Hypertension | 504 (11.97) | 380 (13.39) | 884 (12.54) | 0.077 |
Diabetes Mellitus | 271 (6.44) | 219 (7.72) | 490 (6.95) | 0.038 |
Asthma | 191 (4.54) | 111 (3.91) | 302 (4.28) | 0.204 |
Cardiopathy | 58 (1.38) | 44 (1.55) | 102 (1.45) | 0.551 |
Number of COVID-19 vaccine doses | ||||
None | 1415 (33.60) | 703 (24.77) | 2118 (30.05) | <0.001 |
1st dose | 7 (0.17) | 13 (0.46) | 20 (0.28) | |
2nd dose | 1114 (26.45) | 490 (17.27) | 1604 (22.76) | |
3rd dose | 1368 (32.49) | 1377 (48.52) | 2745 (38.94) | |
4th dose | 307 (7.29) | 255 (8.99) | 562 (7.97) |
Variable/Category | Odds Ratio (OR) | 95%CI Lower | 95%CI Upper | p Value |
---|---|---|---|---|
Sex | ||||
Females | Reference category | |||
Males | 0.99 | 0.84 | 1.18 | 0.990 |
Age group | ||||
18 to 29 | 1.56 | 1.25 | 1.94 | <0.001 |
40 to 49 | 1.22 | 0.99 | 1.50 | 0.058 |
50 to 59 | 1.63 | 1.29 | 2.05 | <0.001 |
60 to 69 | 2.25 | 1.50 | 3.37 | <0.001 |
>70 years | 5.71 | 2.08 | 15.63 | 0.001 |
Previous COVID-19 infections | ||||
Yes | 26.95 | 21.88 | 33.20 | <0.001 |
Health care workers (HCW) | ||||
Nurse | Reference category | |||
Medical resident | 2.79 | 2.08 | 3.74 | <0.001 |
Medical student | 2.22 | 1.38 | 3.54 | 0.001 |
Medical staff | 2.21 | 1.63 | 2.97 | <0.001 |
Administratives | 1.11 | 0.91 | 1.34 | 0.300 |
General services | 1.32 | 0.94 | 1.84 | 0.104 |
Paramedics | 1.62 | 1.21 | 2.17 | 0.001 |
Reserchers | 1.96 | 1.25 | 3.09 | 0.003 |
Vaccine periods | ||||
Wave 1 to 3 | 16.06 | 10.40 | 24.81 | <0.001 |
Wave 4 to 6 | 11.65 | 9.23 | 14.70 | <0.001 |
Wave 7 to Post-COVID-19 Emergency | Reference category | |||
Self-reported symptomatology | ||||
Chills | 1.20 | 1.01 | 1.42 | 0.032 |
Fever | 1.75 | 1.47 | 2.10 | <0.001 |
Anosmya | 1.56 | 1.10 | 2.22 | 0.011 |
Cough | 2.42 | 2.07 | 2.83 | <0.001 |
Diahrrea | 0.71 | 0.59 | 0.86 | <0.001 |
Mialgya | 1.30 | 1.09 | 1.54 | 0.003 |
Self-reported Comorbidities | ||||
Obesity | 0.81 | 0.66 | 0.97 | 0.026 |
Immunization scheme | ||||
0 to 1 | 1.01 | 0.64 | 1.58 | 0.978 |
2 to 3 | 0.67 | 0.51 | 0.89 | 0.005 |
4 doses | Reference category |
Variable | Non-Severe COVID-19 n = 2790 | Severe COVID-19 n = 48 | Total n = 2838 | p Value |
---|---|---|---|---|
Sex | ||||
Female | 1748 (62.65) | 27 (56.25) | 1775 (62.54) | 0.364 |
Male | 1042 (37.35) | 21 (43.75) | 1063 (37.46) | |
Age group | ||||
18 to 29 | 609 (21.83) | 2 (4.17) | 611 (21.53) | 0.001 |
30 to 39 | 715 (25.63) | 6 (12.50) | 721 (25.41) | |
40 to 49 | 795 (28.49) | 21 (43.75) | 816 (28.75) | |
50 to 59 | 518 (18.57) | 13 (27.08) | 531 (18.71) | |
60 to 69 | 132 (4.73) | 5 (10.42) | 137 (4.83) | |
70 to 90 | 21 (0.75) | 1 (2.08) | 22 (0.78) | |
Occupation | ||||
Nurse | 960 (34.42) | 13 (27.08) | 973 (34.30) | 0.03 |
Medical resident | 265 (9.50) | 3 (6.25) | 268 (9.45) | |
Medical student | 68 (2.44) | 0 (0.00) | 68 (2.40) | |
Medical staff | 238 (8.53) | 7 (14.58) | 245 (8.64) | |
Administratives | 744 (26.68) | 20 (41.67) | 764 (26.93) | |
General services | 174 (6.24) | 5 (10.42) | 179 (6.31) | |
Paramedics | 260 (9.32) | 0 (0.00) | 260 (9.16) | |
Researchers | 80 (2.87) | 0 (0.00) | 80 (2.82) | |
Clinical and pidemiological characteristics | ||||
Smoking | 170 (6.09) | 3 (6.25) | 173 (6.10) | 0.964 |
Epidemiological wave | ||||
Wave 1 | 253 (9.07) | 17 (35.42) | 270 (9.51) | <0.001 |
Wave 2 | 392 (14.05) | 23 (47.92) | 415 (14.62) | |
Wave 3 | 124 (4.44) | 3 (6.25) | 127 (4.47) | |
Wave 4 | 661 (23.69) | 3 (6.25) | 664 (23.40) | |
Wave 5 | 777 (27.85) | 0 (0.00) | 777 (27.38) | |
Wave 6 | 187 (6.70) | 0 (0.00) | 187 (6.59) | |
Wave 7 | 76 (2.72) | 0 (0.00) | 76 (2.68) | |
Wave 8 | 320 (11.47) | 2 (4.17) | 322 (11.35) | |
Signs and symptoms | ||||
Cough | 1902 (68.17) | 34 (70.83) | 1936 (68.22) | 0.695 |
Rhinorrhea | 1242 (44.52) | 15 (31.25) | 1257 (44.29) | 0.067 |
Chills | 1205 (43.19) | 26 (54.17) | 1231 (43.38) | 0.128 |
Fever | 1013 (36.31) | 30 (62.50) | 1043 (36.75) | <0.001 |
Myalgias | 937 (33.58) | 18 (37.50) | 955 (33.65) | 0.569 |
Generalized Attack | 699 (25.05) | 14 (29.17) | 713 (25.12) | 0.515 |
Arthralgias | 690 (23.73) | 17 (35.42) | 707 (24.91) | 0.139 |
Dyspnea | 244 (8.75) | 12 (25.0) | 256 (9.02) | <0.001 |
Pharyngodynia | 662 (23.73) | 7 (14.58) | 669 (23.57) | 0.139 |
Chest Pain | 549 (19.68) | 7 (14.58) | 556 (19.59) | 0.378 |
Alertness | 535 (19.18) | 6 (12.50) | 541 (19.06) | 0.243 |
Diarrhea | 456 (16.34) | 14 (29.17) | 470 (16.56) | 0.018 |
Vomiting | 115 (4.12) | 5 (10.42) | 120 (4.23) | 0.032 |
Abdominal Pain | 317 (11.36) | 4 (8.33) | 321 (11.31) | 0.511 |
Dysphonia | 144 (5.16) | 1 (2.08) | 145 (5.11) | 0.337 |
Dysgeusia | 137 (4.91) | 1 (2.08) | 138 (4.86) | 0.367 |
Comorbidities | ||||
Obesity | 466 (16.70) | 17 (35.42) | 483 (17.02) | 0.001 |
Hypertension | 362 (12.97) | 18 (37.50) | 380 (13.39) | <0.001 |
Diabetes Mellitus | 212 (7.60) | 7 (14.58) | 219 (7.72) | 0.072 |
Asthma | 110 (3.94) | 1 (2.08) | 111 (3.91) | 0.51 |
Cardiopathy | 39 (1.40) | 5 (10.42) | 44 (1.55) | <0.001 |
Number of COVID-19 vaccine dosis | ||||
None | 663 (23.76) | 40 (83.33) | 703 (24.77) | <0.001 |
1st dose | 13 (0.47) | 0 (0.00) | 13 (0.46) | <0.001 |
2nd dose | 484 (17.35) | 6 (12.50) | 490 (17.27) | <0.001 |
3rd dose | 1376 (49.32) | 1 (2.08) | 1377 (48.52) | <0.001 |
4th dose | 254 (9.10) | 1 (2.08) | 255 (8.99) | <0.001 |
Variable/Category | Odds Ratio (OR) | 95%CI Lower | 95%CI Upper | p Value |
---|---|---|---|---|
Sex | ||||
Male | 1.0 | 0.49 | 2.03 | 0.987 |
Age group | ||||
18 to 29 | 0.51 | 0.09 | 2.65 | 0.427 |
30 to 39 | Reference category | |||
40 to 49 | 3.72 | 1.2 | 11.46 | 0.022 |
50 to 59 | 3.44 | 1.02 | 11.6 | 0.046 |
60 to 69 | 6.98 | 1.53 | 31.71 | 0.012 |
>70 years | 14.09 | 1.21 | 163.87 | 0.035 |
Health care workers (HCW) | ||||
Nurse | Reference category | |||
Medical resident | 4.09 | 0.83 | 19.97 | 0.082 |
Medical student | 1.0 | (empty) * | (empty) * | (empty) * |
Medical doctor | 1.77 | 0.58 | 5.4 | 0.311 |
Administratives | 1.61 | 0.72 | 3.59 | 0.236 |
General services | 1.12 | 0.32 | 3.88 | 0.855 |
Paramedics | 1 | (empty) * | (empty) * | (empty) * |
Reserchers and academics | 1 | (empty) * | (empty) * | (empty) * |
Epidemiological waves | ||||
Wave 1 to 3 | 11.11 | 1.12 | 110.21 | 0.040 |
Wave 4 to 6 | 1.28 | 0.22 | 7.2 | 0.778 |
Wave 7 to Post-COVID-19 Emergency | Reference category | |||
Self-reported symtomatology | ||||
Fever | 6.63 | 1.91 | 6.88 | <0.001 |
Self-reported Comorbidities | ||||
Obesity | 2.33 | 1.17 | 4.63 | 0.015 |
Hypertension | 2.61 | 1.28 | 5.33 | 0.008 |
Diabetes | 1.61 | 0.62 | 4.12 | 0.321 |
Immunization scheme | ||||
0 to 1 | 2.70 | 0.16 | 43.83 | 0.484 |
2 to 3 | 1.11 | 0.11 | 10.74 | 0.931 |
4 doses | Reference category |
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Jiménez-Corona, M.E.; Cruz-Hervert, L.-P.; Sánchez-Díaz, M.d.R.; Chavira-Trujillo, G.; Jiménez-Corona, A.; Vázquez-Larios, M.d.R. COVID-19 Vaccination Uptake and Effectiveness for Hospitalized Cases Among Healthcare Workers in Tertiary Hospital. Vaccines 2025, 13, 147. https://doi.org/10.3390/vaccines13020147
Jiménez-Corona ME, Cruz-Hervert L-P, Sánchez-Díaz MdR, Chavira-Trujillo G, Jiménez-Corona A, Vázquez-Larios MdR. COVID-19 Vaccination Uptake and Effectiveness for Hospitalized Cases Among Healthcare Workers in Tertiary Hospital. Vaccines. 2025; 13(2):147. https://doi.org/10.3390/vaccines13020147
Chicago/Turabian StyleJiménez-Corona, María Eugenia, Luis-Pablo Cruz-Hervert, María del Rocío Sánchez-Díaz, Gabriel Chavira-Trujillo, Aída Jiménez-Corona, and María del Rosario Vázquez-Larios. 2025. "COVID-19 Vaccination Uptake and Effectiveness for Hospitalized Cases Among Healthcare Workers in Tertiary Hospital" Vaccines 13, no. 2: 147. https://doi.org/10.3390/vaccines13020147
APA StyleJiménez-Corona, M. E., Cruz-Hervert, L.-P., Sánchez-Díaz, M. d. R., Chavira-Trujillo, G., Jiménez-Corona, A., & Vázquez-Larios, M. d. R. (2025). COVID-19 Vaccination Uptake and Effectiveness for Hospitalized Cases Among Healthcare Workers in Tertiary Hospital. Vaccines, 13(2), 147. https://doi.org/10.3390/vaccines13020147