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Vaccines
Volume 10
Issue 4
10.3390/vaccines10040613
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Brief Report

Prolonged Protective Immunity Induced by Mild SARS-CoV-2 Infection of K18-hACE2 Mice

by
Liat Bar-On
1,*,
Moshe Aftalion
1,
Efi Makdasi
2,
David Gur
1,
Ron Alcalay
1,
Hila Cohen
1,
Adi Beth-Din
1,
Ronit Rosenfeld
1,
Hagit Achdout
2,
Erez Bar-Haim
1,
Reut Falach
1,
Theodor Chitlaru
1 and
Ofer Cohen
1,*
1
Biochemistry and Molecular Genetics Department, Israel Institute for Biological Research, Ness-Ziona 74100, Israel
2
Infectious Diseases Department, Israel Institute for Biological Research, Ness-Ziona 74100, Israel
*
Authors to whom correspondence should be addressed.
Vaccines 2022, 10(4), 613; https://doi.org/10.3390/vaccines10040613
Submission received: 16 March 2022 / Revised: 11 April 2022 / Accepted: 12 April 2022 / Published: 14 April 2022
(This article belongs to the Special Issue Feature Papers of Pathogens-Host Immune Interface)
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Abstract

Longevity of the immune response following viral exposure is an essential aspect of SARS-CoV-2 infection. Mild SARS-CoV-2 infection of K18-hACE2 mice was implemented for evaluating the mounting and longevity of a specific memory immune response. We show that the infection of K18-hACE2 mice induced robust humoral and cellular immunity (systemic and local), which persisted for at least six months. Virus-specific T cells and neutralizing antibody titers decreased over time, yet their levels were sufficient to provide sterile immunity against lethal rechallenge six months post-primary infection. The study substantiates the role of naturally induced immunity against SARS-CoV-2 infection for preventing recurring morbidity.
Keywords: SARS-CoV-2; COVID-19; K18-hACE2 mice; mild infection SARS-CoV-2; COVID-19; K18-hACE2 mice; mild infection

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MDPI and ACS Style

Bar-On, L.; Aftalion, M.; Makdasi, E.; Gur, D.; Alcalay, R.; Cohen, H.; Beth-Din, A.; Rosenfeld, R.; Achdout, H.; Bar-Haim, E.; et al. Prolonged Protective Immunity Induced by Mild SARS-CoV-2 Infection of K18-hACE2 Mice. Vaccines 2022, 10, 613. https://doi.org/10.3390/vaccines10040613

AMA Style

Bar-On L, Aftalion M, Makdasi E, Gur D, Alcalay R, Cohen H, Beth-Din A, Rosenfeld R, Achdout H, Bar-Haim E, et al. Prolonged Protective Immunity Induced by Mild SARS-CoV-2 Infection of K18-hACE2 Mice. Vaccines. 2022; 10(4):613. https://doi.org/10.3390/vaccines10040613

Chicago/Turabian Style

Bar-On, Liat, Moshe Aftalion, Efi Makdasi, David Gur, Ron Alcalay, Hila Cohen, Adi Beth-Din, Ronit Rosenfeld, Hagit Achdout, Erez Bar-Haim, and et al. 2022. "Prolonged Protective Immunity Induced by Mild SARS-CoV-2 Infection of K18-hACE2 Mice" Vaccines 10, no. 4: 613. https://doi.org/10.3390/vaccines10040613

APA Style

Bar-On, L., Aftalion, M., Makdasi, E., Gur, D., Alcalay, R., Cohen, H., Beth-Din, A., Rosenfeld, R., Achdout, H., Bar-Haim, E., Falach, R., Chitlaru, T., & Cohen, O. (2022). Prolonged Protective Immunity Induced by Mild SARS-CoV-2 Infection of K18-hACE2 Mice. Vaccines, 10(4), 613. https://doi.org/10.3390/vaccines10040613

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