Antibody and T Cell Responses against SARS-CoV-2 Elicited by the Third Dose of BBIBP-CorV (Sinopharm) and BNT162b2 (Pfizer-BioNTech) Vaccines Using a Homologous or Heterologous Booster Vaccination Strategy
Abstract
:1. Introduction
2. Materials and Methods
2.1. Determination of SARS-CoV-2-Specific T Cell Response
2.2. Determination of SARS-CoV-2-Specific Antibody Response
2.3. SARS-CoV-2-Specific Antibody and T Cell Responses 6 Months after Two-Dose BBIBP-CorV or BNT162b2 Vaccine Regimen
2.4. SARS-CoV-2-Specific Antibody and T Cell Responses after Third BNT162b2 Vaccine following a Two-Dose BNT162b2 or BBIBP-CorV Vaccine Regimen, or after Third BBIBP-CorV Vaccine following a Two-Dose BNT162b2 Vaccine Regimen
2.5. Statistical Analysis
3. Results
3.1. Antibody and T Cell Responses against SARS-CoV-2 6 Months after Immunization with Two-Dose BNT162b2 or BBIBP-CorV Vaccine
3.2. SARS-CoV-2-Specific Antibody and T Cell Responses after the Third (Booster) Dose of BNT162b2 or BBIBP-CorV Vaccines
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Matula, Z.; Gönczi, M.; Bekő, G.; Kádár, B.; Ajzner, É.; Uher, F.; Vályi-Nagy, I. Antibody and T Cell Responses against SARS-CoV-2 Elicited by the Third Dose of BBIBP-CorV (Sinopharm) and BNT162b2 (Pfizer-BioNTech) Vaccines Using a Homologous or Heterologous Booster Vaccination Strategy. Vaccines 2022, 10, 539. https://doi.org/10.3390/vaccines10040539
Matula Z, Gönczi M, Bekő G, Kádár B, Ajzner É, Uher F, Vályi-Nagy I. Antibody and T Cell Responses against SARS-CoV-2 Elicited by the Third Dose of BBIBP-CorV (Sinopharm) and BNT162b2 (Pfizer-BioNTech) Vaccines Using a Homologous or Heterologous Booster Vaccination Strategy. Vaccines. 2022; 10(4):539. https://doi.org/10.3390/vaccines10040539
Chicago/Turabian StyleMatula, Zsolt, Márton Gönczi, Gabriella Bekő, Béla Kádár, Éva Ajzner, Ferenc Uher, and István Vályi-Nagy. 2022. "Antibody and T Cell Responses against SARS-CoV-2 Elicited by the Third Dose of BBIBP-CorV (Sinopharm) and BNT162b2 (Pfizer-BioNTech) Vaccines Using a Homologous or Heterologous Booster Vaccination Strategy" Vaccines 10, no. 4: 539. https://doi.org/10.3390/vaccines10040539