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Article

Gam-COVID-Vac (Sputnik V) and Pfizer-BioNTech Vaccines Adverse Events following Immunization in Patients Affected by Parkinson’s Disease and Multiple Sclerosis: A Longitudinal Study

1
School of Hygiene and Preventive Medicine, Department of Biomedical and Neuromotor Sciences, Public Health and Medical Statistics, University of Bologna, 40126 Bologna, Italy
2
San Marino Neurological Unit, State Hospital of the Republic of San Marino, 47893 Cailungo, San Marino
3
Unit of Hygiene, Department of Biomedical and Neuromotor Sciences, Public Health and Medical Statistics, University of Bologna, 40126 Bologna, Italy
4
San Marino Central Pharmacy, San Marino Hospital, 47893 Cailungo, San Marino
*
Author to whom correspondence should be addressed.
Academic Editor: Giuseppe La Torre
Vaccines 2022, 10(3), 370; https://doi.org/10.3390/vaccines10030370
Received: 15 February 2022 / Revised: 22 February 2022 / Accepted: 24 February 2022 / Published: 26 February 2022
(This article belongs to the Special Issue Feature Papers of Epidemiology and Vaccines)
The Republic of San Marino COVID-19 vaccination campaign used Gam-COVID-Vac and Pfizer-BioNTech vaccines. To assess adverse events following immunization (AEFIs), approximately 6000 vaccine recipients were monitored by the ROCCA study, including subgroups with Parkinson’s Disease (PD) and Multiple Sclerosis (MS). The purpose of this study is to evaluate short-term AEFIs through a 1-month follow-up. We conducted a longitudinal study, using active surveillance to evaluate the safety profiles of COVID-19 vaccines in PD and MS patients. Participants were actively administered a standardized online questionnaire to collect information on AEFIs. Among all PD and MS assisted by the San Marino hospital, a total of 82 patients completed the questionnaires. One week after administration of the first dose, vaccine recipients reported AEFIs in 26% of cases in the PD group, 67% in the MS group, and 68% in the control group. Participants reported slightly higher rates of AEFIs after dose 2 compared with dose 1, being 29%, 75%, and 78% for PD, MS, control group, respectively. Most of the reported symptoms were mild. Patients with PD and MS reported few AEFIs after administration of the COVID-19 vaccines. The frequency of AEFIs in the PD population was significantly lower than in the control group. View Full-Text
Keywords: AEFI; adverse event; vaccination; Gam-COVID-Vac; Pfizer-BioNTech; Parkinson’s disease; Multiple Sclerosis AEFI; adverse event; vaccination; Gam-COVID-Vac; Pfizer-BioNTech; Parkinson’s disease; Multiple Sclerosis
MDPI and ACS Style

Soldà, G.; Barvas, E.; Lenzi, J.; Di Valerio, Z.; La Fauci, G.; Guttmann, S.; Riccardi, R.; Fantini, M.P.; Salussolia, A.; Montalti, M.; Gori, D. Gam-COVID-Vac (Sputnik V) and Pfizer-BioNTech Vaccines Adverse Events following Immunization in Patients Affected by Parkinson’s Disease and Multiple Sclerosis: A Longitudinal Study. Vaccines 2022, 10, 370. https://doi.org/10.3390/vaccines10030370

AMA Style

Soldà G, Barvas E, Lenzi J, Di Valerio Z, La Fauci G, Guttmann S, Riccardi R, Fantini MP, Salussolia A, Montalti M, Gori D. Gam-COVID-Vac (Sputnik V) and Pfizer-BioNTech Vaccines Adverse Events following Immunization in Patients Affected by Parkinson’s Disease and Multiple Sclerosis: A Longitudinal Study. Vaccines. 2022; 10(3):370. https://doi.org/10.3390/vaccines10030370

Chicago/Turabian Style

Soldà, Giorgia, Edoardo Barvas, Jacopo Lenzi, Zeno Di Valerio, Giusy La Fauci, Susanna Guttmann, Rossano Riccardi, Maria P. Fantini, Aurelia Salussolia, Marco Montalti, and Davide Gori. 2022. "Gam-COVID-Vac (Sputnik V) and Pfizer-BioNTech Vaccines Adverse Events following Immunization in Patients Affected by Parkinson’s Disease and Multiple Sclerosis: A Longitudinal Study" Vaccines 10, no. 3: 370. https://doi.org/10.3390/vaccines10030370

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