Vaccine Coverage against Influenza and SARS-CoV-2 in Health Sciences Students during COVID-19 Pandemic in Spain
Abstract
:1. Introduction
2. Materials and Methods
3. Results
3.1. Influenza Vaccination Coverage
3.2. Vaccination Coverage against SARS-CoV-2
4. Discussion
4.1. Influenza Vaccination Coverage
4.2. Vaccination Coverage against SARS-CoV-2
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Acknowledgments
Conflicts of Interest
References
- Karafillakis, E.; Dinca, I.; Apfel, F.; Cecconi, S.; Wűrz, A.; Takacs, J.; Suk, J.; Celentano, L.P.; Kramarz, P.; Larson, H.J. Vaccine hesitancy among healthcare workers in Europe: A qualitative study. Vaccine 2016, 34, 5013–5020. [Google Scholar] [CrossRef] [PubMed]
- Yaqub, O.; Castle-Clarke, S.; Sevdalis, N.; Chataway, J. Attitudes to vaccination: A critical review. Soc. Sci. Med. 2014, 112, 18. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Cvjetkovic, S.J.; Jeremic, V.L.; Tiosavljevic, D.V. Knowledge and attitudes toward vaccination: A survey of Serbian students. J. Infect. Public Heal. 2017, 10, 649–656. [Google Scholar] [CrossRef] [PubMed]
- Pelly, L.P.; MacDougall, D.M.P.; Halperin, B.A.; Strang, R.A.; Bowles, S.K.; Baxendale, D.M.; McNeil, S.A. THE VAXED PROJECT: An Assessment of Immunization Education in Canadian Health Professional Programs. BMC Med. Educ. 2010, 10, 86. [Google Scholar] [CrossRef] [Green Version]
- Dybsand, L.L.; Hall, K.J.; Carson, P.J. Immunization attitudes, opinions, and knowledge of healthcare professional students at two Midwestern universities in the United States. BMC Med. Educ. 2019, 19, 16788. [Google Scholar] [CrossRef]
- Berera, D.; Thompson, K.M. Medical Student Knowledge, Attitudes, and Practices Regarding Immunization. J. Vaccines Vaccin. 2012, 6, 268. [Google Scholar] [CrossRef] [Green Version]
- Secretaria General de Sanidad. Ministerio de Sanidad. Gobierno de España. Actualización na 484. Enfermedad por el Coronavirus (COVID-19). 2021. Available online: https://www.sanidad.gob.es/profesionales/saludPublica/ccayes/alertasActual/nCov/documentos/Actualizacion_484_COVID-19.pdf (accessed on 21 December 2021).
- De Figueiredo, A.; Karafillakis, E.; Larson, P.H.J. A Report for the European Commission Written by State of Vaccine Confidence in the EU+UK 2020 TM; European Commission: Geneva, Switzerland, 2020; pp. 1–54. [Google Scholar]
- Domnich, A.; Grassi, R.; Fallani, E.; Spurio, A.; Bruzzone, B.; Panatto, D.; Marozzi, B.; Cambiaggi, M.; Vasco, A.; Orsi, A.; et al. Changes in Attitudes and Beliefs Concerning Vaccination and Influenza Vaccines between the First and Second COVID-19 Pandemic Waves: A Longitudinal Study. Vaccines 2021, 9, 1016. [Google Scholar] [CrossRef]
- Del Riccio, M.; Lina, B.; Caini, S.; Staadegaard, L.; Wiegersma, S.; Kynčl, J.; Combadière, B.; MacIntyre, C.R.; Paget, J. Letter to the editor: Increase of influenza vaccination coverage rates during the COVID-19 pandemic and implications for the upcoming influenza season in northern hemisphere countries and Australia. Eurosurveillance 2021, 26, 2101143. [Google Scholar] [CrossRef]
- García, A.; Prada, M.F.; Aristegui, J.; Moreno, D.; Redondo, E.; Jimeno, I.; García Cenoz, M.; Lopez Trigo, J.A. Documento de Actualización y Reflexión Sobre la Vacunación Antigripal en España; Esmon Publicidad, SA: Barcelona, Spain, 2018. [Google Scholar]
- Iacobucci, G. Covid-19: Risk of death more than doubled in people who also had flu, English data show. BMJ 2020, 370, 3720. [Google Scholar] [CrossRef]
- Stowe, J.; Tessier, E.; Zhao, H.; Guy, R.; Muller-Pebody, B.; Zambon, M.; Andrews, N.; Ramsay, M.; Bernal, J.L. Interactions between SARS-CoV-2 and influenza, and the impact of coinfection on disease severity: A test-negative design. Int. J. Epidemiol. 2021, 50, 1124–1133. [Google Scholar] [CrossRef]
- Ministerio de Sanidad. Nota Informativa en Relación a a la Vacuna Frente a Gripe y Covid-19. 2020. Available online: https://www.sanidad.gob.es/profesionales/saludPublica/prevPromocion/vacunaciones/docs/COVID-19_Vacunaciongripe.pdf (accessed on 15 December 2021).
- World Health Organization. Gripe (Estacional). 2020. Available online: https://www.who.int/es/news-room/fact-sheets/detail/influenza-(seasonal) (accessed on 15 December 2021).
- Consejo Interterritorial Sistema Nacional de Salud. Recomendaciones de Vacunación Frente a la Gripe Temporada 2020–2021. 2020. Available online: https://www.sanidad.gob.es/profesionales/saludPublica/prevPromocion/vacunaciones/programasDeVacunacion/docs/Recomendaciones_vacunacion_gripe.pdf (accessed on 15 December 2021).
- Bonaccorsi, G.; Lorini, C.; Porchia, B.R.; Niccolai, G.; Martino, G.; Giannarelli, L.; Santomauro, F. Influenza vaccination: Coverage and risk perception among students of the health professions at Florence University, Italy. Ann. Ig. 2013, 25, 181–189. [Google Scholar] [CrossRef] [PubMed]
- Rachiotis, G.; Papagiannis, D.; Malli, F.; Papathanasiou, I.V.; Kotsiou, O.; Fradelos, E.C.; Daniil, Z.; Gourgoulianis, K.I. Determinants of Influenza Vaccination Coverage among Greek Health Care Workers amid COVID-19 Pandemic. Infect. Dis. Rep. 2021, 13, 757–762. [Google Scholar] [CrossRef] [PubMed]
- Fernández-Prada, M.; Ramos-Martín, P.; Madroñal-Menéndez, J.; Martínez-Ortega, C.; González-Cabrera, J. Design and Validation of a Questionnaire on Vaccination in Students of Health Sciences, Spain. Rev. Esp. Salud Publica 2016, 90, e1–e10. [Google Scholar]
- Talarek, E.; Warzecha, J.; Banasiuk, M.; Banaszkiewicz, A. Influenza Vaccination Coverage and Intention to Receive Hypothetical Ebola and COVID-19 Vaccines among Medical Students. Vaccines 2021, 9, 709. [Google Scholar] [CrossRef] [PubMed]
- Mitchell, G.; Leonard, L.; Carter, G.; Santin, O.; Wilson, C.B. Evaluation of a ‘serious game’ on nursing student knowledge and uptake of influenza vaccination. PLoS ONE 2021, 16, e0245389. [Google Scholar] [CrossRef]
- Rogers, C.J.; Bahr, K.O.; Benjamin, S.M. Attitudes and barriers associated with seasonal influenza vaccination uptake among public health students; a cross-sectional study. BMC Public Health 2018, 18, 1131. [Google Scholar] [CrossRef]
- Ghandora, H.; Halperin, D.M.; Isenor, J.E.; Taylor, B.A.; Fullsack, P.; Di Castri, A.M.; Halperin, S.A. Knowledge, attitudes, behaviours, and beliefs of healthcare provider students regarding mandatory influenza vaccination. Hum. Vaccines Immunother. 2018, 15, 700–709. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Fergus, E.; Speare, R.; Heal, C. Immunisation Rates of Medical Students at a Tropical Queensland University. Trop. Med. Infect. Dis. 2018, 3, 52. [Google Scholar] [CrossRef] [Green Version]
- Banaszkiewicz, A.; Talarek, E.; Śliwka, J.; Kazubski, F.; Małecka, I.; Stryczyńska-Kazubska, J.; Dziubak, W.; Kuchar, E. Awareness of Influenza and Attitude toward Influenza Vaccination among Medical Students. In Pulmonary Dysfunction and Disease; Springer: Cham, Switzerland, 2016; Volume 934, pp. 83–88. [Google Scholar] [CrossRef]
- Kawahara, Y.; Nishiura, H. Exploring Influenza Vaccine Uptake and Its Determinants among University Students: A Cross-Sectional Study. Vaccines 2020, 8, 52. [Google Scholar] [CrossRef] [Green Version]
- Cheung, K.; Ho, S.M.S.; Lam, W. Factors affecting the willingness of nursing students to receive annual seasonal influenza vaccination: A large-scale cross-sectional study. Vaccine 2017, 35, 1482–1487. [Google Scholar] [CrossRef]
- Costantino, C.; Mazzucco, W.; Azzolini, E.; Baldini, C.; Bergomi, M.; Biafiore, A.D.; Bianco, M.; Borsari, L.; Cacciari, P.; Cadeddu, C.; et al. Influenza vaccination coverage among medical residents. Hum. Vaccines Immunother. 2014, 10, 1204–1210. [Google Scholar] [CrossRef] [PubMed]
- Saied, S.M.; Saied, E.M.; Kabbash, I.A.; Abdo, S.A.E. Vaccine hesitancy: Beliefs and barriers associated with COVID-19 vaccination among Egyptian medical students. J. Med Virol. 2021, 93, 4280–4291. [Google Scholar] [CrossRef] [PubMed]
- Baccolini, V.; Renzi, E.; Isonne, C.; Migliara, G.; Massimi, A.; De Vito, C.; Marzuillo, C.; Villari, P. COVID-19 Vaccine Hesitancy among Italian University Students: A Cross-Sectional Survey during the First Months of the Vaccination Campaign. Vaccines 2021, 9, 1292. [Google Scholar] [CrossRef] [PubMed]
- Tavolacci, M.; Dechelotte, P.; Ladner, J. COVID-19 Vaccine Acceptance, Hesitancy, and Resistancy among University Students in France. Vaccines 2021, 9, 654. [Google Scholar] [CrossRef] [PubMed]
- Abohelwa, M.; Elmassry, M.; Abdelmalek, J.; Payne, D.; Nugent, K. 2019 Novel Coronavirus Vaccination among Post-graduate Residents and Fellows. J. Prim. Care Community Health 2021, 12, 22978. [Google Scholar] [CrossRef]
- Sovicova, M.; Zibolenova, J.; Svihrova, V.; Hudeckova, H. Odds Ratio Estimation of Medical Students’ Attitudes towards COVID-19 Vaccination. Int. J. Environ. Res. Public Health 2021, 18, 6815. [Google Scholar] [CrossRef]
- Sugawara, N.; Yasui-Furukori, N.; Fukushima, A.; Shimoda, K. Attitudes of Medical Students toward COVID-19 Vaccination: Who Is Willing to Receive a Third Dose of the Vaccine? Vaccines 2021, 9, 1295. [Google Scholar] [CrossRef]
- Al-Mohaithef, M.; Padhi, B.K. Determinants of COVID-19 Vaccine Acceptance in Saudi Arabia: A Web-Based National Survey. J. Multidiscip. Health 2020, 13, 1657–1663. [Google Scholar] [CrossRef]
- Sallam, M.; Dababseh, D.; Eid, H.; Hasan, H.; Taim, D.; Al-Mahzoum, K.; Al-Haidar, A.; Yaseen, A.; Ababneh, N.; Assaf, A.; et al. Low COVID-19 Vaccine Acceptance Is Correlated with Conspiracy Beliefs among University Students in Jordan. Int. J. Environ. Res. Public Health 2021, 18, 2407. [Google Scholar] [CrossRef]
- Rosental, H.; Shmueli, L. Integrating Health Behavior Theories to Predict COVID-19 Vaccine Acceptance: Differences between Medical Students and Nursing Students. Vaccines 2021, 9, 783. [Google Scholar] [CrossRef]
- Jehi, L.; Ji, X.; Milinovich, A.; Erzurum, S.; Merlino, A.; Gordon, S.; Young, J.B.; Kattan, M.W. Development and validation of a model for individualized prediction of hospitalization risk in 4,536 patients with COVID-19. PLoS ONE 2020, 15, e0237419. [Google Scholar] [CrossRef] [PubMed]
- Ragni, P.; Marino, M.; Formisano, D.; Bisaccia, E.; Scaltriti, S.; Bedeschi, E.; Grilli, R. Association between Exposure to Influenza Vaccination and COVID-19 Diagnosis and Outcomes. Vaccines 2020, 8, 675. [Google Scholar] [CrossRef] [PubMed]
- Sallam, M.; Dababseh, D.; Eid, H.; Al-Mahzoum, K.; Al-Haidar, A.; Taim, D.; Yaseen, A.; Ababneh, N.A.; Bakri, F.G.; Mahafzah, A. High Rates of COVID-19 Vaccine Hesitancy and Its Association with Conspiracy Beliefs: A Study in Jordan and Kuwait among Other Arab Countries. Vaccines 2021, 9, 42. [Google Scholar] [CrossRef] [PubMed]
- Al Dossary, R.; Alnimr, A.; Aljindan, R.; Alkharsah, K.R.; Al-Qurayn, A.K.; Eltreifi, O.; Alkuwaiti, F.A.; Almashouf, A.B.; Alsahlawi, A.M.; Alshammari, A.; et al. Predictors of Illness Severity in COVID-19 Cases in Saudi Arabia. Infect. Drug Resist. 2021, 14, 4097–4105. [Google Scholar] [CrossRef]
- Bozkurt, F.T.; Tercan, M.; Patmano, G.; Tanrıverdi, T.B.; Demir, H.A.; Yurekli, U.F. Can Ferritin Levels Predict the Severity of Illness in Patients With COVID-19? Cureus 2021, 13, 12832. [Google Scholar] [CrossRef]
Variables | Total (Q1,Q2) n (%) | Q1 n (%) | Q2 n (%) | |
---|---|---|---|---|
Sex | Female | 1532 (80.9) | 743 (48.5) | 789 (51.5) |
Male | 362 (19.1) | 191 (52.8) | 171 (47.2) | |
Aggregate age | <21 years old | 1176 (62.1) | 591 (50.3) | 585 (49.7) |
≥21 years | 718 (37.9) | 343 (47.8) | 375 (52.2) | |
Degree | Nursing | 1336 (70.5) | 624 (46.7) | 712 (53.3) |
Physiotherapy | 266 (14.0) | 162(60.9) | 104 (39.1) | |
Podiatry | 292 (15.4) | 148(50.7) | 144 (49.3) | |
Grade | 1 | 547 (28.9) | 292 (53.4) | 255 (46.6) |
2 | 509 (26.9) | 300 (58.9) | 209 (41.1) | |
3 | 431 (22.8) | 178 (41.3) | 253 (58.7) | |
4 | 407 (21.5) | 164 (40.3) | 243 (59.7) |
Variables | Categories | Q1 n (%) | Q2 n (%) | p-Value |
---|---|---|---|---|
Sex | Female | 202 (27.2) | 277 (35.1) | p < 0.0001 |
Male | 48 (25.1) | 59 (34.7) | 0.031 | |
Age | <21 years | 155 (26.2) | 175 (30.0) | 0.087 |
≥21 years | 95 (27.7) | 161 (42.9) | p < 0.0001 | |
Degree | Nursing | 203 (32.5) | 278 (39.0) | 0.008 |
Physiotherapy | 29 (17.9) | 26 (25.0) | 0.108 | |
Chiropody | 18 (12.2) | 32 (22.4) | 0.015 | |
Course year for all degrees taken together | 1st | 38 (13.0) | 62 (24.3) | p < 0.0001 |
2nd | 121 (40.3) | 84 (40.2) | 0.524 | |
3rd | 56 (31.5) | 72 (28.6) | 0.295 | |
4th | 35 (21.3) | 118(48.6) | p < 0.0001 |
Variables | Q2 | p-Value | |
---|---|---|---|
n (%) | |||
Country of birth | Spain | 305 (35.2) | 0.717 |
Other | 31 (33.3) | ||
Has been vaccinated against SARS-CoV-2 | Yes | 333 (35.5) | 0.044 |
No | 3 (14.3) | ||
Has been diagnosed with COVID-19? | Yes | 81 (35.5) | 0.859 |
No | 255 (34.9) | ||
Type of symptomatology after being diagnosed with COVID | I have not passed COVID infection 19 | 248 (34.7) | 0.813 |
Asymptomatic | 22 (32.8) | ||
Mild case | 63 (36.6) | ||
Severe | 3 (50.0) | ||
Has anyone you know close to you been COVID-19 | Yes | 152 (34.9) | 0.956 |
No | 184 (35.1) | ||
Do you live with people at risk? | Yes | 159 (42.1) | p < 0.001 |
No | 177 (30.5) |
Dependent Variable | Independent Variables | Coefficients B | OR (95%CI) | p Value |
---|---|---|---|---|
Vaccination to influenza | Course Year 4th (vs. 1°, 2° y 3°) | 0.929 | 2.53 (1.83–3.50) | p < 0.001 |
Nursing (vs. Physiotherapy and Podiatry) | 0.682 | 1.98 (1.41–2.77) | p < 0.001 | |
Course Year 2rd (vs. 1°, 3° y 4°) | 0.663 | 1.94 (1.37–2.74) | p < 0.001 | |
Cohabitation with at-risk patient (vs. no cohabitation) | 0.514 | 1.67 (1.27–2.21) | p < 0.001 | |
Constant | −1756 | 0.063 | 0.007 |
Variables | Q2 n (%) | |
---|---|---|
Has been vaccinated against SARS-CoV-2 | Yes | 939 (97.8) |
No | 21 (2.2) | |
Has been diagnosed with COVID-19? | Yes | 245 (25.6) |
No | 715 (74.4) | |
Type of symptomatology after being diagnosed with COVID | Asymptomatic | 67 (27.3) |
Mild case | 172 (70.2) | |
Severe | 6 (2.5) | |
Has anyone close to you been a COVID-19 case? | Yes | 436 (45.4) |
No | 524 (54.6) | |
Do you live with people at risk? | Yes | 379 (39.5) |
No | 581 (60.5) |
Variables | Asymptomatic | Mild Clinical | Sever Clinical | p-Value | |
---|---|---|---|---|---|
Sex | Female | 46 (68.7) | 148 (86.0) | 5 (83.3) | 0.144 |
Male | 21 (31.3) | 24 (14.0) | 1 (16.7) | ||
Age | <21 years old | 42 (62.7) | 111 (64.5) | 1 (16.7) | 0.017 |
≥21 years old | 25 (37.3) | 61 (35.5) | 5 (83.3) | ||
Country of birth | Spain | 57 (85.1) | 149 (86.6) | 6 (100.0) | 0.079 |
Others | 10 (14.9) | 23 (13.4) | 0 (0.0) | ||
Grade | Nursing | 42 (62.7) | 136 (79.1) | 5 (83.3) | 0.016 |
Physiotherapy | 16 (23.9) | 16 (9.3) | 0 (0.0) | ||
Podiatry | 9 (13.4) | 20 (11.6) | 1 (16.7) | ||
Course | 1 | 17 (25.4) | 57 (33.1) | 3 (50.0) | 0.069 |
2 | 11 (16.4) | 26 (15.1) | 0 (0.0) | ||
3 | 23 (34.3) | 50 (29.1) | 2 (33.3) | ||
4 | 16 (23.9) | 39 (22.7) | 1 (16.7) | ||
Influenza vaccinated Q2 | Yes | 22 (32.8) | 63 (36.6) | 3 (50.0) | 0.813 |
No | 45 (67.2) | 109 (63.4) | 3 (50.0) | ||
COVID-19 vaccinated | Yes | 63 (94.0) | 162 (94.2) | 6 (100.0) | p < 0.001 |
No | 4 (6.0) | 10 (5.8) | 0 (0.0) |
Dependent Variable | Independent Variables | Coefficients B | OR (95%CI) | p Value |
---|---|---|---|---|
Vaccination to SARS-CoV-2 | Have passed the COVID infection | −1.329 | 0.27 (0.12–0.65) | 0.003 |
Have been vaccinated against influenza | 1.21 | 3.36 (0.98–11.54) | 0.054 | |
Constant | 3.994 | 54.28 | p < 0.001 |
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Ajejas Bazán, M.J.; Del Gallego-Lastra, R.; Marques-Vieira, C.M.A.; López-López, C.; Domínguez-Fernández, S.; Rico-Blázquez, M.; Pérez-Rivas, F.J. Vaccine Coverage against Influenza and SARS-CoV-2 in Health Sciences Students during COVID-19 Pandemic in Spain. Vaccines 2022, 10, 159. https://doi.org/10.3390/vaccines10020159
Ajejas Bazán MJ, Del Gallego-Lastra R, Marques-Vieira CMA, López-López C, Domínguez-Fernández S, Rico-Blázquez M, Pérez-Rivas FJ. Vaccine Coverage against Influenza and SARS-CoV-2 in Health Sciences Students during COVID-19 Pandemic in Spain. Vaccines. 2022; 10(2):159. https://doi.org/10.3390/vaccines10020159
Chicago/Turabian StyleAjejas Bazán, María Julia, Ramón Del Gallego-Lastra, Cristina Maria Alves Marques-Vieira, Candelas López-López, Silvia Domínguez-Fernández, Milagros Rico-Blázquez, and Francisco Javier Pérez-Rivas. 2022. "Vaccine Coverage against Influenza and SARS-CoV-2 in Health Sciences Students during COVID-19 Pandemic in Spain" Vaccines 10, no. 2: 159. https://doi.org/10.3390/vaccines10020159
APA StyleAjejas Bazán, M. J., Del Gallego-Lastra, R., Marques-Vieira, C. M. A., López-López, C., Domínguez-Fernández, S., Rico-Blázquez, M., & Pérez-Rivas, F. J. (2022). Vaccine Coverage against Influenza and SARS-CoV-2 in Health Sciences Students during COVID-19 Pandemic in Spain. Vaccines, 10(2), 159. https://doi.org/10.3390/vaccines10020159