Laboratory Indicators for Identifying Hand, Foot, and Mouth Disease Severity: A Systematic Review and Meta-Analysis
Abstract
:1. Introduction
2. Materials and Methods
2.1. Diagnosis and Group Classification
2.2. Literature Search Strategy
2.3. Inclusion and Exclusion Criteria
2.4. Data Extraction and Quality Assessment
2.5. Statistical Analysis
3. Results
3.1. Study Inclusion and Characteristics
3.2. Results of the Meta-Analysis
3.3. Subgroup Analysis
3.4. Publication Bias
3.5. Sensitivity Analysis
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Literature Number | Author | Time Span | Sample Size | Sex Ratio | Average Age | Pathogen | NOS |
---|---|---|---|---|---|---|---|
1 | Zhang A et al. | 2014.4–2015.3 | 83 | 1.19 | 2.23 | EVA71 | 6 |
2 | Zeng M et al. | 2010.7–2010.9 | 40 | 4 | 2.77 | EVA71 | 8 |
3 | Wang W et al. | 2012.5–2012.7 | 84 | 1.8 | 2.66 | EVA71 | 5 |
4 | Qiu J et al. | 2012.1–2014.12 | 362 | 1.74 | 1.75 | EVA71, CVA16 | 6 |
5 | Liu G et al. | 2012.3–2015.7 | 2532 | 2.1 | 2 | EVA71 | 7 |
6 | Liu C et al. | 2012.1–2015.12 | 717 | 1.73 | 2.5 | EVA71 | 5 |
7 | Li W et al. | 2012.3–2012.10 | 571 | 1.59 | 2.58 | EVA71 | 7 |
8 | Li Q et al. | 2018.1–2018.12 | 53 | 3.08 | 2.67 | EVA71 | 7 |
9 | Hua Y et al. | 2014–2015 | 52 | 1.6 | 2.8 | EVA71 | 6 |
10 | Duan G et al. | 2012.4–2012.11 | 102 | 1.55 | 1.93 | EVA71 | 7 |
11 | Dang HX et al. | 2015.6–2016.9 | 89 | NR | 2.32 | EVA71 | 8 |
12 | Cai K et al. | 2014.1–2016.12 | 190 | NR | NR | EVA71 | 6 |
13 | Cai K et al. | 2014.1–2016.12 | 234 | NR | NR | CVA16 | 6 |
14 | Dang H et al. | 2015.6–2018.3 | 111 | 1.27 | 2.5 | EVA71, CVA16 | 7 |
15 | He Y et al. | 2012–2014 | 132 | 1.93 | 2.85 | EVA71 | 7 |
16 | Li Q et al. | 2017.6–2018.6 | 58 | 3.46 | 2.63 | EVA71 | 7 |
17 | Pan J et al. | 2008–2009 | 369 | 1.88 | 4.17 | EVA71, CVA16 | 5 |
18 | Song CL et al. | 2010.5–2012.9 | 164 | 1.88 | NR | EVA71, CVA16 | 6 |
19 | Xu Y et al. | 2012.4–2013.9 | 107 | 1.49 | 2.33 | EVA71 | 5 |
20 | Yang X et al. | 2017.1–2017.12 | 261 | 1.43 | 1.69 | CVA6 | 6 |
21 | Zheng G et al. | 2009.1–2016.12 | 179 | 1.67 | 2.04 | EVA71 | 5 |
22 | Zhou H et al. | 2008.5–2011.11 | 2379 | 1.39 | 3.2 | EVA71, CVA16 | 6 |
23 | Shen Y et al. | 2017.8–2018.3 | 66 | 1.64 | 2.49 | EVA71 | 6 |
24 | Yang T et al. | 2010.1–2011.6 | 356 | 1.87 | 2.11 | EVA71 | 6 |
25 | Li S et al. | 2011.5–2011.8 | 95 | 1.32 | 2.02 | EVA71 | 6 |
26 | Zhu L et al. | 2013.1–2016.1 | 76 | 1.53 | 4.64 | EVA71 | 6 |
27 | Zheng W et al. | 2014.7–2015.7 | 70 | 0.79 | 2.18 | EVA71 | 6 |
28 | Zhu H et al. | 2018.3 | 39 | 1.29 | 2 | NR | 6 |
29 | Han F et al. | 2013.7–2015.7 | 300 | 1.38 | 2.7 | EVA71, CVA16 | 5 |
30 | Chen M et al. | 2013.1–2014.6 | 240 | 1.06 | 1.85 | EVA71 | 5 |
31 | Sui M et al. | 2013.4–2013.6 | 100 | 1.86 | 1.49 | NR | 6 |
Clinical Indicators | Number of Literature | Begg’s Test (p Value) |
---|---|---|
IL-2 | 4 | 1.000 |
IL-10 | 4 | 0.734 |
IL-6 | 5 | 0.806 |
IL-8 | 3 | 1.000 |
IFN-γ | 7 | 0.368 |
TNF-α | 7 | 0.072 |
WBC | 19 | 0.576 |
Blood glucose | 9 | 0.466 |
Lymphocytes | 8 | 0.108 |
Creatinine | 3 | 1.000 |
CK-MB | 7 | 1.000 |
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Xie, Y.; Hu, Q.; Jiang, W.; Ji, W.; Chen, S.; Jin, Y.; Duan, G. Laboratory Indicators for Identifying Hand, Foot, and Mouth Disease Severity: A Systematic Review and Meta-Analysis. Vaccines 2022, 10, 1829. https://doi.org/10.3390/vaccines10111829
Xie Y, Hu Q, Jiang W, Ji W, Chen S, Jin Y, Duan G. Laboratory Indicators for Identifying Hand, Foot, and Mouth Disease Severity: A Systematic Review and Meta-Analysis. Vaccines. 2022; 10(11):1829. https://doi.org/10.3390/vaccines10111829
Chicago/Turabian StyleXie, Yaqi, Quanman Hu, Wenjie Jiang, Wangquan Ji, Shuaiyin Chen, Yuefei Jin, and Guangcai Duan. 2022. "Laboratory Indicators for Identifying Hand, Foot, and Mouth Disease Severity: A Systematic Review and Meta-Analysis" Vaccines 10, no. 11: 1829. https://doi.org/10.3390/vaccines10111829
APA StyleXie, Y., Hu, Q., Jiang, W., Ji, W., Chen, S., Jin, Y., & Duan, G. (2022). Laboratory Indicators for Identifying Hand, Foot, and Mouth Disease Severity: A Systematic Review and Meta-Analysis. Vaccines, 10(11), 1829. https://doi.org/10.3390/vaccines10111829