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Oxidative Stress: Concept and Some Practical Aspects

by 1,2
Institute of Biochemistry and Molecular Biology I, Heinrich-Heine-University Düsseldorf, University Street 1, Bldg 22.04, D-40225 Düsseldorf, Germany
Leibniz Research Institute for Environmental Medicine, Heinrich-Heine-University Düsseldorf, D-40225 Düsseldorf, Germany
Antioxidants 2020, 9(9), 852;
Received: 21 August 2020 / Revised: 2 September 2020 / Accepted: 8 September 2020 / Published: 10 September 2020
(This article belongs to the Special Issue Oxidative Stress, Classification and Quantitation)
Oxidative stress is defined as “an imbalance between oxidants and antioxidants in favor of the oxidants, leading to a disruption of redox signaling and control and/or molecular damage”. This Commentary presents basic features of this global concept which has attracted interest in biology and medicine. The term “antioxidants” in cellular defense against oxidants predominantly includes antioxidant enzymes with their substrates and coenzymes. Exogenous low-molecular-mass compounds also have a role, but this is more limited. Multiple biomarkers of damage due to oxidative stress have been identified for different molecular classes (protein, lipid, carbohydrate, and DNA), and the current state of practical aspects in health and disease is delineated. View Full-Text
Keywords: oxidative stress; antioxidants; biomarkers oxidative stress; antioxidants; biomarkers
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MDPI and ACS Style

Sies, H. Oxidative Stress: Concept and Some Practical Aspects. Antioxidants 2020, 9, 852.

AMA Style

Sies H. Oxidative Stress: Concept and Some Practical Aspects. Antioxidants. 2020; 9(9):852.

Chicago/Turabian Style

Sies, Helmut. 2020. "Oxidative Stress: Concept and Some Practical Aspects" Antioxidants 9, no. 9: 852.

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