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Open AccessReview

Nitric Oxide Nano-Delivery Systems for Cancer Therapeutics: Advances and Challenges

by Long Binh Vong 1,2,* and Yukio Nagasaki 3,4,5,*
1
School of Biomedical Engineering, International University, Ho Chi Minh 700000, Vietnam
2
Vietnam National University Ho Chi Minh City (VNU-HCM), Ho Chi Minh 700000, Vietnam
3
Department of Materials Science, Graduate School of Pure and Applied Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8573, Japan
4
Master’s School of Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8577, Japan
5
Center for Research in Isotopes and Environmental Dynamics (CRiED), University of Tsukuba, Tennoudai 1-1-1, Tsukuba, Ibaraki 305-8573, Japan
*
Authors to whom correspondence should be addressed.
Antioxidants 2020, 9(9), 791; https://doi.org/10.3390/antiox9090791
Received: 31 July 2020 / Revised: 21 August 2020 / Accepted: 25 August 2020 / Published: 26 August 2020
(This article belongs to the Special Issue Delivery of Gaseous Signal Molecules)
Nitric oxide (NO) plays important roles in various physiological and pathological functions and processes in the human body. Therapeutic application of NO molecules has been investigated in various diseases, including cardiovascular disease, cancer, and infections. However, the extremely short half-life of NO, which limits its clinical use considerably, along with non-specific distribution, has resulted in a low therapeutic index and undesired adverse effects. To overcome the drawbacks of using this gaseous signaling molecule, researchers in the last several decades have focused on innovative medical technologies, specifically nanoparticle-based drug delivery systems (DDSs), because these systems alter the biodistribution of the therapeutic agent through controlled release at the target tissues, resulting in a significant therapeutic drug effect. Thus, the application of nano-systems for NO delivery in the field of biomedicine, particularly in the development of new drugs for cancer treatment, has been increasing worldwide. In this review, we discuss NO delivery nanoparticle systems, with the aim of improving drug delivery development for conventional chemotherapies and controlling multidrug resistance in cancer treatments. View Full-Text
Keywords: nitric oxide; drug resistance; self-assembled nanomedicine; gaseous signaling molecule; angiogenesis; cancer nitric oxide; drug resistance; self-assembled nanomedicine; gaseous signaling molecule; angiogenesis; cancer
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MDPI and ACS Style

Vong, L.B.; Nagasaki, Y. Nitric Oxide Nano-Delivery Systems for Cancer Therapeutics: Advances and Challenges. Antioxidants 2020, 9, 791.

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