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Open AccessArticle

Bioprospection of Natural Sources of Polyphenols with Therapeutic Potential for Redox-Related Diseases

1
CEDOC, Chronic Diseases Research Centre, NOVA Medical School/Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, Campo dos Mártires da Pátria, 130, 1169-056 Lisboa, Portugal
2
iBET, Instituto de Biologia Experimental e Tecnológica, Apartado 12, 2781-901 Oeiras, Portugal
3
Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Av. da República, 2780-157 Oeiras, Portugal
4
Environmental and Biochemical Science Group, The James Hutton Institute, Dundee DD2 5DA, UK
5
Biomathematics and Statistics Scotland, Invergowrie, Dundee DD2 5DA, UK
6
Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, University Medical Center Goettinge, 37073 Göttingen, Germany
7
Max Planck Institute for Experimental Medicine, 37075 Göttingen, Germany
8
Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Framlington Place, Newcastle Upon Tyne NE2 4HH, UK
9
School of Engineering and Physical Sciences, Institute of Mechanical, Process and Energy Engineering, Heriot-Watt University, Edinburgh EH14 4AS, UK
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Antioxidants 2020, 9(9), 789; https://doi.org/10.3390/antiox9090789
Received: 22 July 2020 / Revised: 14 August 2020 / Accepted: 18 August 2020 / Published: 26 August 2020
(This article belongs to the Special Issue Redox-Active Molecules as Therapeutic Agents)
Plants are a reservoir of high-value molecules with underexplored biomedical applications. With the aim of identifying novel health-promoting attributes in underexplored natural sources, we scrutinized the diversity of (poly)phenols present within the berries of selected germplasm from cultivated, wild, and underutilized Rubus species. Our strategy combined the application of metabolomics, statistical analysis, and evaluation of (poly)phenols’ bioactivity using a yeast-based discovery platform. We identified species as sources of (poly)phenols interfering with pathological processes associated with redox-related diseases, particularly, amyotrophic lateral sclerosis, cancer, and inflammation. In silico prediction of putative bioactives suggested cyanidin–hexoside as an anti-inflammatory molecule which was validated in yeast and mammalian cells. Moreover, cellular assays revealed that the cyanidin moiety was responsible for the anti-inflammatory properties of cyanidin–hexoside. Our findings unveiled novel (poly)phenolic bioactivities and illustrated the power of our integrative approach for the identification of dietary (poly)phenols with potential biomedical applications. View Full-Text
Keywords: bioactivity-based assays; cyanidin; metabolomics; Rubus genus; (poly)phenols; yeast-based discovery platform bioactivity-based assays; cyanidin; metabolomics; Rubus genus; (poly)phenols; yeast-based discovery platform
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MDPI and ACS Style

Menezes, R.; Foito, A.; Jardim, C.; Costa, I.; Garcia, G.; Rosado-Ramos, R.; Freitag, S.; Alexander, C.J.; Outeiro, T.F.; Stewart, D.; Santos, C.N. Bioprospection of Natural Sources of Polyphenols with Therapeutic Potential for Redox-Related Diseases. Antioxidants 2020, 9, 789.

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