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Review

Potential Health Benefit of Garlic Based on Human Intervention Studies: A Brief Overview

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Dipartimento di Scienze Cliniche Specialistiche e Odontostomtologiche—Università Politecnica delle Marche, Via Ranieri 65, 60130 Ancona, Italy
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Nutrition and Food Science Group, department of Analytical and Food Chemistry, CITACA, CACTI, University of Vigo-Vigo Campus, 36310 Vigo, Spain
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Nutrition and Food Science Group, Department of Biochemistry, Genetics and Immunology, Faculty of Biology, University of Vigo, 36310 Vigo, Spain
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Dipartimento di Scienze Cliniche e Molecolari, Facoltà di Medicina, Università Politecnica delle Marche, 60131 Ancona, Italy
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Nutrition and Bromatology Group, Department of Analytical and Food Chemistry, Faculty of Science, University of Vigo, Ourense Campus, E-32004 Ourense, Spain
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College of Food Science and Technology, Northwest University, Xi’an, Shaanxi 710069, China
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International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang 212013, China
*
Authors to whom correspondence should be addressed.
These authors have contributed equally.
Antioxidants 2020, 9(7), 619; https://doi.org/10.3390/antiox9070619
Received: 28 May 2020 / Revised: 24 June 2020 / Accepted: 13 July 2020 / Published: 15 July 2020
Garlic is a polyphenolic and organosulfur enriched nutraceutical spice consumed since ancient times. Garlic and its secondary metabolites have shown excellent health-promoting and disease-preventing effects on many human common diseases, such as cancer, cardiovascular and metabolic disorders, blood pressure, and diabetes, through its antioxidant, anti-inflammatory, and lipid-lowering properties, as demonstrated in several in vitro, in vivo, and clinical studies. The present review aims to provide a comprehensive overview on the consumption of garlic, garlic preparation, garlic extract, and garlic extract-derived bioactive constituents on oxidative stress, inflammation, cancer, cardiovascular and metabolic disorders, skin, bone, and other common diseases. Among the 83 human interventional trials considered, the consumption of garlic has been reported to modulate multiple biomarkers of different diseases; in addition, its combination with drugs or other food matrices has been shown to be safe and to prolong their therapeutic effects. The rapid metabolism and poor bioavailability that have limited the therapeutic use of garlic in the last years are also discussed. View Full-Text
Keywords: garlic; sulfur-containing compounds; polyphenols health benefits; metabolism and bioavailability garlic; sulfur-containing compounds; polyphenols health benefits; metabolism and bioavailability
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MDPI and ACS Style

Ansary, J.; Forbes-Hernández, T.Y.; Gil, E.; Cianciosi, D.; Zhang, J.; Elexpuru-Zabaleta, M.; Simal-Gandara, J.; Giampieri, F.; Battino, M. Potential Health Benefit of Garlic Based on Human Intervention Studies: A Brief Overview. Antioxidants 2020, 9, 619. https://doi.org/10.3390/antiox9070619

AMA Style

Ansary J, Forbes-Hernández TY, Gil E, Cianciosi D, Zhang J, Elexpuru-Zabaleta M, Simal-Gandara J, Giampieri F, Battino M. Potential Health Benefit of Garlic Based on Human Intervention Studies: A Brief Overview. Antioxidants. 2020; 9(7):619. https://doi.org/10.3390/antiox9070619

Chicago/Turabian Style

Ansary, Johura, Tamara Y. Forbes-Hernández, Emilio Gil, Danila Cianciosi, Jiaojiao Zhang, Maria Elexpuru-Zabaleta, Jesus Simal-Gandara, Francesca Giampieri, and Maurizio Battino. 2020. "Potential Health Benefit of Garlic Based on Human Intervention Studies: A Brief Overview" Antioxidants 9, no. 7: 619. https://doi.org/10.3390/antiox9070619

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