The Interplay between Oxidative Stress and miRNAs in Obesity-Associated Hepatic and Vascular Complications

Laboratory of Hepatic and Cardiovascular Diseases, Biochemistry and Molecular Biology Department, School of Pharmacy, Complutense University of Madrid, 28040 Madrid, Spain

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These authors contributed equally.

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Co-senior authors.

Antioxidants 2020, 9(7), 607; https://doi.org/10.3390/antiox9070607

Received: 12 June 2020 / Revised: 2 July 2020 / Accepted: 9 July 2020 / Published: 10 July 2020

(This article belongs to the Special Issue Oxidative Stress in Obesity)

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Abstract

Nowadays, the obesity pandemic is one of the most relevant health issues worldwide. This condition is tightly related to comorbidities such as non-alcoholic fatty liver disease (NAFLD) and cardiovascular diseases (CVDs), namely atherosclerosis. Dysregulated lipid metabolism and inflammation link these three diseases, leading to a subsequent increase of oxidative stress (OS) causing severe cellular damage. On the other hand, microRNAs (miRNAs) are short, single-stranded, non-coding RNAs that act as post-transcriptional negative regulators of gene expression, thus being involved in the molecular mechanisms that promote the development of many pathologies including obesity and its comorbidities. The involvement of miRNAs in promoting or opposing OS in disease progression is becoming more evident. Some miRNAs, such as miR-200a and miR.421, seem to play important roles in OS control in NAFLD. On the other hand, miR-92a and miR-133, among others, are important in the development of atherosclerosis. Moreover, since both diseases are linked to obesity, they share common altered miRNAs, being miR-34a and miR-21 related to OS. This review summarizes the latest advances in the knowledge about the mechanisms of oxidative stress (OS) generation in obesity-associated NAFLD and atherosclerosis, as well as the role played by miRNAs in the regulation of such mechanisms. View Full-Text

Keywords: obesity; non-alcoholic fatty liver disease; atherosclerosis; cardiovascular diseases; oxidative stress; reactive oxygen species; mitochondrial dysfunction; NADPH oxidases; antioxidants; microRNAs

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MDPI and ACS Style

Infante-Menéndez, J.; López-Pastor, A.R.; González-López, P.; Gómez-Hernández, A.; Escribano, O. The Interplay between Oxidative Stress and miRNAs in Obesity-Associated Hepatic and Vascular Complications. Antioxidants 2020, 9, 607. https://doi.org/10.3390/antiox9070607

AMA Style

Infante-Menéndez J, López-Pastor AR, González-López P, Gómez-Hernández A, Escribano O. The Interplay between Oxidative Stress and miRNAs in Obesity-Associated Hepatic and Vascular Complications. Antioxidants. 2020; 9(7):607. https://doi.org/10.3390/antiox9070607

Chicago/Turabian Style

Infante-Menéndez, Jorge, Andrea R. López-Pastor, Paula González-López, Almudena Gómez-Hernández, and Oscar Escribano. 2020. "The Interplay between Oxidative Stress and miRNAs in Obesity-Associated Hepatic and Vascular Complications" Antioxidants 9, no. 7: 607. https://doi.org/10.3390/antiox9070607

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The Interplay between Oxidative Stress and miRNAs in Obesity-Associated Hepatic and Vascular Complications

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