Next Article in Journal
Vitamin D3 Supplementation in Drinking Water Prior to Slaughter Improves Oxidative Status, Physiological Stress, and Quality of Pork
Next Article in Special Issue
Effects of Supplementation with Natural Antioxidants on Oocytes and Preimplantation Embryos
Previous Article in Journal
Effects of Darkness and Light Spectra on Nutrients and Pigments in Radish, Soybean, Mung Bean and Pumpkin Sprouts
Previous Article in Special Issue
Esculetin as a Bifunctional Antioxidant Prevents and Counteracts the Oxidative Stress and Neuronal Death Induced by Amyloid Protein in SH-SY5Y Cells
Open AccessReview

Update on the Effects of Antioxidants on Diabetic Retinopathy: In Vitro Experiments, Animal Studies and Clinical Trials

1
Department of Ophthalmology, General University Hospital Morales Meseguer, 30007 Murcia, Spain
2
Department of Ophthalmology and Optometry, University of Murcia, 30120 Murcia, Spain
3
Ophthalmic Research Unit Santiago Grisolia, 46017 Valencia, Spain
4
Cellular and Molecular Ophthalmolobiology Group, Surgery Department of the University of Valencia, 46010 Valencia, Spain
5
Red Temática de Investigación Cooperativa en Patología Ocular (OFTARED), Instituto de Salud Carlos III, 28029 Madrid, Spain
6
Department of Surgery & Hospital Clinic de Barcelona (IDIBAPS), School of Medicine, University of Barcelona, E-08036 Barcelona, Spain
7
Institute of Biomedical Research (IIB-Sant Pau—SGR1113), Banc de Sang i Texits (BST), E-08041 Barcelona, Spain
8
Area of Health Sciences, Valencian International University, 46002 Valencia, Spain
9
Department of Anaesthesiology, University Hospital Virgen de la Arrixaca, 30120 Murcia, Spain
*
Authors to whom correspondence should be addressed.
V.Z.-M. and M.d.-R.-V. shared last authorship as senior authors.
Antioxidants 2020, 9(6), 561; https://doi.org/10.3390/antiox9060561
Received: 7 June 2020 / Revised: 22 June 2020 / Accepted: 23 June 2020 / Published: 26 June 2020
Current therapies for diabetic retinopathy (DR) incorporate blood glucose and blood pressure control, vitrectomy, photocoagulation, and intravitreal injections of anti-vascular endothelial growth factors or corticosteroids. Nonetheless, these techniques have not been demonstrated to completely stop the evolution of this disorder. The pathophysiology of DR is not fully known, but there is more and more evidence indicating that oxidative stress is an important mechanism in the progression of DR. In this sense, antioxidants have been suggested as a possible therapy to reduce the complications of DR. In this review we aim to assemble updated information in relation to in vitro experiments, animal studies and clinical trials dealing with the effect of the antioxidants on DR. View Full-Text
Keywords: diabetic retinopathy; antioxidant; oxidative stress; retina; in vitro; cell; animal; clinical trial; human; patient diabetic retinopathy; antioxidant; oxidative stress; retina; in vitro; cell; animal; clinical trial; human; patient
MDPI and ACS Style

Garcia-Medina, J.J.; Rubio-Velazquez, E.; Foulquie-Moreno, E.; Casaroli-Marano, R.P.; Pinazo-Duran, M.D.; Zanon-Moreno, V.; del-Rio-Vellosillo, M. Update on the Effects of Antioxidants on Diabetic Retinopathy: In Vitro Experiments, Animal Studies and Clinical Trials. Antioxidants 2020, 9, 561.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop