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Development of Multifunctional Cosmetic Cream Using Bioactive Materials from Streptomyces sp. T65 with Synthesized Mesoporous Silica Particles SBA-15

1
Department of Life Science, College of Natural Sciences, Kyonggi University, Suwon, Gyeonggi-Do 16227, Korea
2
Institute of Life Sciences, Thai Nguyen University of Agriculture and Forestry, Quyet Thang, Thai Nguyen 250-000, Vietnam
3
Innogene, Co., #301 Woolim E-biz Center1, 28, Digital-ro 33-gil, Guro-gu, Seoul 08337, Korea
4
Gyeonggi Small & Medium Business Growth Accelerating Center, 304ho, Suseong-ro 8, Gwonseon-gu, Suwon 16426, Korea
*
Author to whom correspondence should be addressed.
Antioxidants 2020, 9(4), 278; https://doi.org/10.3390/antiox9040278
Received: 26 February 2020 / Revised: 11 March 2020 / Accepted: 23 March 2020 / Published: 26 March 2020
Various cosmetics having a single function are increasingly being used, but cosmetics having multifunctional activities remain limited. We aimed to develop a multifunctional cosmetic cream having antioxidant, anti-tyrosinase, anti-aging and antimicrobial activities. Antimicrobial activities were performed by disc-diffusion method. Cell toxicity and cell proliferations were evaluated in a 96-well plate with different cell lines such as HaCaT, RAW264.7, CCD-986Sk, B16F1, and B16F10. Mushroom tyrosinase inhibition, elastase inhibition, and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activities were evaluated and IC50 was calculated. Mesoporous silica particle was synthesized using Pluronic P123 and tetraethyl ortho-silicate (TEOS). Facial pictures were captured by VISIA-CR (Facial Imaging System for Clinical Research). Roughness of image was analysed by PRIMOS software and brightness of image was analyzed by Chromameter CR-400. The crude product of strain T65 inhibited the different human pathogenic bacteria such as Bacillus subtilis, Escherichia coli, Propionibacterium acnes, Staphylococcus aureus, Pseudomonas aeruginosa, and Staphylococcus epidermidis. The IC50 of T65 crude product for mushroom tyrosinase, elastase, and DPPH radical scavenging activities were 58.73, 14.68, and 6.31 µg/mL, respectively. T65 crude product proliferated collagen type I in CCD-986Sk cell up to 145.91% ± 9.11% (mean ± SD; mean of 24, 48, and 72 h) at 250 pg/mL. Synthesized mesoporous particles (SBA-15) confirmed the sustainable performance by control-release for three days. Formulated functional cosmetic cream containing T65 embedded SBA-15, significantly decreased the skin roughness by 4.670% and increased the skin brightness by 0.472% after application of 4 weeks. T65 crude product inhibited both Gram-positive and Gram-negative pathogens. Synthesized mesoporous particle, SBA-15, confirmed the physiologically active substance was released in sustainable release condition. T65 crude product showed impeccable antimicrobial, antioxidant, anti-aging, and whitening activities with non-cytotoxic effects to different cell lines related to the human skin. View Full-Text
Keywords: antioxidant; cytotoxicity; anti-tyrosinase; anti-aging; antimicrobial; mesoporous silica particles; cosmeceutical formulations; aesthetic application antioxidant; cytotoxicity; anti-tyrosinase; anti-aging; antimicrobial; mesoporous silica particles; cosmeceutical formulations; aesthetic application
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MDPI and ACS Style

Dahal, R.H.; Nguyen, T.M.; Shim, D.S.; Kim, J.Y.; Lee, J.; Kim, J. Development of Multifunctional Cosmetic Cream Using Bioactive Materials from Streptomyces sp. T65 with Synthesized Mesoporous Silica Particles SBA-15. Antioxidants 2020, 9, 278. https://doi.org/10.3390/antiox9040278

AMA Style

Dahal RH, Nguyen TM, Shim DS, Kim JY, Lee J, Kim J. Development of Multifunctional Cosmetic Cream Using Bioactive Materials from Streptomyces sp. T65 with Synthesized Mesoporous Silica Particles SBA-15. Antioxidants. 2020; 9(4):278. https://doi.org/10.3390/antiox9040278

Chicago/Turabian Style

Dahal, Ram H.; Nguyen, Tuan M.; Shim, Dong S.; Kim, Joon Y.; Lee, Jangyul; Kim, Jaisoo. 2020. "Development of Multifunctional Cosmetic Cream Using Bioactive Materials from Streptomyces sp. T65 with Synthesized Mesoporous Silica Particles SBA-15" Antioxidants 9, no. 4: 278. https://doi.org/10.3390/antiox9040278

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