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Targeting Heme Oxygenase-1 in Cardiovascular and Kidney Disease

1
Department of Physiology and Biophysics, Mississippi Center for Obesity Research, University of Mississippi Medical Center, Jackson, MI 39216, USA
2
Departments of Medicine and Pharmacology, New York Medical College, Vahalla, NY 10595, USA
3
Joan C. Edwards School of Medicine, Marshall University, Huntington, VA 25701, USA
*
Author to whom correspondence should be addressed.
Antioxidants 2019, 8(6), 181; https://doi.org/10.3390/antiox8060181
Received: 3 June 2019 / Revised: 13 June 2019 / Accepted: 15 June 2019 / Published: 18 June 2019
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Abstract

Heme oxygenase (HO) plays an important role in the cardiovascular system. It is involved in many physiological and pathophysiological processes in all organs of the cardiovascular system. From the regulation of blood pressure and blood flow to the adaptive response to end-organ injury, HO plays a critical role in the ability of the cardiovascular system to respond and adapt to changes in homeostasis. There have been great advances in our understanding of the role of HO in the regulation of blood pressure and target organ injury in the last decade. Results from these studies demonstrate that targeting of the HO system could provide novel therapeutic opportunities for the treatment of several cardiovascular and renal diseases. The goal of this review is to highlight the important role of HO in the regulation of cardiovascular and renal function and protection from disease and to highlight areas in which targeting of the HO system needs to be translated to help benefit patient populations. View Full-Text
Keywords: bilirubin; carbon monoxide; hypertension; kidney injury; blood pressure bilirubin; carbon monoxide; hypertension; kidney injury; blood pressure
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Drummond, H.A.; Mitchell, Z.L.; Abraham, N.G.; Stec, D.E. Targeting Heme Oxygenase-1 in Cardiovascular and Kidney Disease. Antioxidants 2019, 8, 181.

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