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Juglone in Oxidative Stress and Cell Signaling

College of Pharmacy, University of Sargodha, Sargodha, Punjab 40100, Pakistan
Department of Pharmacology and Physiology, Georgetown University Medical Center, Washington, DC 20007, USA
Author to whom correspondence should be addressed.
Antioxidants 2019, 8(4), 91;
Received: 25 February 2019 / Revised: 23 March 2019 / Accepted: 1 April 2019 / Published: 5 April 2019
(This article belongs to the Special Issue Novel Aspects of Redox, Antioxidant and Mitochondrial Signaling)
PDF [1007 KB, uploaded 19 April 2019]


Juglone (5-hydroxyl-1,4-naphthoquinone) is a phenolic compound found in walnuts. Because of the antioxidant capacities of phenolic compounds, juglone may serve to combat oxidative stress, thereby protecting against the development of various diseases and aging processes. However, being a quinone molecule, juglone could also act as a redox cycling agent and produce reactive oxygen species. Such prooxidant properties of juglone may confer health effects, such as by killing cancer cells. Further, recent studies revealed that juglone influences cell signaling. Notably, juglone is an inhibitor of Pin1 (peptidyl-prolyl cis/trans isomerase) that could regulate phosphorylation of Tau, implicating potential effects of juglone in Alzheimer’s disease. Juglone also activates mitogen-activated protein kinases that could promote cell survival, thereby protecting against conditions such as cardiac injury. This review describes recent advances in the understanding of the effects and roles of juglone in oxidative stress and cell signaling. View Full-Text
Keywords: antioxidants; juglone; naphthoquinone; Pin1; redox; signal transduction; walnuts antioxidants; juglone; naphthoquinone; Pin1; redox; signal transduction; walnuts

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Ahmad, T.; Suzuki, Y.J. Juglone in Oxidative Stress and Cell Signaling. Antioxidants 2019, 8, 91.

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