Next Article in Journal
Polyphenolic Composition of Rosa canina, Rosa sempervivens and Pyrocantha coccinea Extracts and Assessment of Their Antioxidant Activity in Human Endothelial Cells
Next Article in Special Issue
Metabolomics Studies to Assess Biological Functions of Vitamin E Nicotinate
Previous Article in Journal
Antioxidant Activities of Alkyl Substituted Pyrazine Derivatives of Chalcones—In Vitro and In Silico Study
Previous Article in Special Issue
Oxidant-Mediated Protein Amino Acid Conversion
Open AccessReview

Juglone in Oxidative Stress and Cell Signaling

College of Pharmacy, University of Sargodha, Sargodha, Punjab 40100, Pakistan
Department of Pharmacology and Physiology, Georgetown University Medical Center, Washington, DC 20007, USA
Author to whom correspondence should be addressed.
Antioxidants 2019, 8(4), 91;
Received: 25 February 2019 / Revised: 23 March 2019 / Accepted: 1 April 2019 / Published: 5 April 2019
(This article belongs to the Special Issue Novel Aspects of Redox, Antioxidant and Mitochondrial Signaling)
Juglone (5-hydroxyl-1,4-naphthoquinone) is a phenolic compound found in walnuts. Because of the antioxidant capacities of phenolic compounds, juglone may serve to combat oxidative stress, thereby protecting against the development of various diseases and aging processes. However, being a quinone molecule, juglone could also act as a redox cycling agent and produce reactive oxygen species. Such prooxidant properties of juglone may confer health effects, such as by killing cancer cells. Further, recent studies revealed that juglone influences cell signaling. Notably, juglone is an inhibitor of Pin1 (peptidyl-prolyl cis/trans isomerase) that could regulate phosphorylation of Tau, implicating potential effects of juglone in Alzheimer’s disease. Juglone also activates mitogen-activated protein kinases that could promote cell survival, thereby protecting against conditions such as cardiac injury. This review describes recent advances in the understanding of the effects and roles of juglone in oxidative stress and cell signaling. View Full-Text
Keywords: antioxidants; juglone; naphthoquinone; Pin1; redox; signal transduction; walnuts antioxidants; juglone; naphthoquinone; Pin1; redox; signal transduction; walnuts
Show Figures

Figure 1

MDPI and ACS Style

Ahmad, T.; Suzuki, Y.J. Juglone in Oxidative Stress and Cell Signaling. Antioxidants 2019, 8, 91.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop