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Open AccessReview

Oleuropein, a Bioactive Compound from Olea europaea L., as a Potential Preventive and Therapeutic Agent in Non-Communicable Diseases

1
Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, viale Morgagni 50, 50134 Florence, Italy
2
PHYTOLAB (Pharmaceutical, Cosmetic, Food Supplement, Technology and Analysis)-DiSIA, University of Florence, Via U. Schiff, 6, 50019 Sesto Fiorentino, Florence, Italy
3
Istituto Toscano Tumori and Center of Excellence for Research, Transfer and High Education (DENOTHE), University of Florence, Piazza di San Marco 4, 50121 Florence, Italy
*
Author to whom correspondence should be addressed.
Antioxidants 2019, 8(12), 578; https://doi.org/10.3390/antiox8120578
Received: 3 October 2019 / Revised: 16 November 2019 / Accepted: 19 November 2019 / Published: 22 November 2019
Growing scientific literature data suggest that the intake of natural bioactive compounds plays a critical role in preventing or reducing the occurrence of human chronic non-communicable diseases (NCDs). Oleuropein, the main phenolic component of Olea europaea L., has attracted scientific attention for its several health beneficial properties such as antioxidant, anti-inflammatory, cardio- and neuro-protective, and anti-cancer. This article is a narrative review focused on the current literature concerning the effect of oleuropein in NCDs, such as neuro- and cardiovascular diseases, diabetes mellitus, chronic kidney diseases, and cancer, by its putative antioxidant and anti-inflammatory activity, but also for its other peculiar actions such as an autophagy inducer and amyloid fibril growth inhibitor and, finally, for its anti-cancer effect. Despite the increasing number of published studies, looking at the beneficial effects of oleuropein, there is limited clinical evidence focused on the benefits of this polyphenol as a nutraceutical product in humans, and many problems are still to be resolved about its bioavailability, bioaccessibility, and dosage. Thus, future clinical randomized trials are needed to establish the relation between the beneficial effects and the mechanisms of action occurring in the human body in response to the intake of oleuropein. View Full-Text
Keywords: Olea europaea L.; oleuropein; extra-virgin olive oil; health effects; non-communicable diseases; oxidative stress; inflammation; autophagy; amyloid Olea europaea L.; oleuropein; extra-virgin olive oil; health effects; non-communicable diseases; oxidative stress; inflammation; autophagy; amyloid
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MDPI and ACS Style

Nediani, C.; Ruzzolini, J.; Romani, A.; Calorini, L. Oleuropein, a Bioactive Compound from Olea europaea L., as a Potential Preventive and Therapeutic Agent in Non-Communicable Diseases. Antioxidants 2019, 8, 578.

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