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Open AccessReview

Nitric Oxide-Releasing Polymeric Materials for Antimicrobial Applications: A Review

by Fan Rong 1,2,†, Yizhang Tang 1,2,†, Tengjiao Wang 1,*,†, Tao Feng 1, Jiang Song 1,3, Peng Li 1,* and Wei Huang 1
1
Xi’an Institute of Flexible Electronics & Xi’an Institute of Biomedical Materials & Engineering, Northwestern Polytechnical University, 127 West Youyi Road, Xi’an 710072, Shaanxi, China
2
Department of Applied Chemistry, School of Natural and Applied Science, Northwestern Polytechnical University, 127 West Youyi Road, Xi’an 710072, Shaanxi, China
3
School of Electronics & Information, Northwestern Polytechnical University, 127 West Youyi Road, Xi’an 710072, Shaanxi, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Antioxidants 2019, 8(11), 556; https://doi.org/10.3390/antiox8110556
Received: 22 October 2019 / Revised: 7 November 2019 / Accepted: 13 November 2019 / Published: 15 November 2019
(This article belongs to the Special Issue Delivery of Gaseous Signal Molecules)
Polymeric materials releasing nitric oxide have attracted significant attention for therapeutic use in recent years. As one of the gaseous signaling agents in eukaryotic cells, endogenously generated nitric oxide (NO) is also capable of regulating the behavior of bacteria as well as biofilm formation in many metabolic pathways. To overcome the drawbacks caused by the radical nature of NO, synthetic or natural polymers bearing NO releasing moiety have been prepared as nano-sized materials, coatings, and hydrogels. To successfully design these materials, the amount of NO released within a certain duration, the targeted pathogens and the trigger mechanisms upon external stimulation with light, temperature, and chemicals should be taken into consideration. Meanwhile, NO donors like S-nitrosothiols (RSNOs) and N-diazeniumdiolates (NONOates) have been widely utilized for developing antimicrobial polymeric agents through polymer-NO donor conjugation or physical encapsulation. In addition, antimicrobial materials with visible light responsive NO donor are also reported as strong and physiological friendly tools for rapid bacterial clearance. This review highlights approaches to delivery NO from different types of polymeric materials for combating diseases caused by pathogenic bacteria, which hopefully can inspire researchers facing common challenges in the coming ‘post-antibiotic’ era. View Full-Text
Keywords: nitric oxide; NO releasing polymer; anti-bacterial; anti-biofilm; biomedical device nitric oxide; NO releasing polymer; anti-bacterial; anti-biofilm; biomedical device
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MDPI and ACS Style

Rong, F.; Tang, Y.; Wang, T.; Feng, T.; Song, J.; Li, P.; Huang, W. Nitric Oxide-Releasing Polymeric Materials for Antimicrobial Applications: A Review. Antioxidants 2019, 8, 556.

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