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Open AccessArticle

Polyphenolic Fraction from Olive Mill Wastewater: Scale-Up and in Vitro Studies for Ophthalmic Nutraceutical Applications

1
National Research Council of Italy, Institute of Biomolecular Chemistry (CNR–ICB), Via Paolo Gaifami 18, 95126 Catania, Italy
2
MEDIVIS, Corso Italia, 171, 95127 Catania, Italy
3
Envisep srl–Z.Ind. VIII Strada, 29-95121 Catania, Italy
*
Authors to whom correspondence should be addressed.
Antioxidants 2019, 8(10), 462; https://doi.org/10.3390/antiox8100462
Received: 2 September 2019 / Revised: 2 October 2019 / Accepted: 4 October 2019 / Published: 8 October 2019
(This article belongs to the Special Issue Polyphenolic Antioxidants from Agri-Food Waste Biomass)
The valorization of food wastes is a challenging opportunity for a green, sustainable, and competitive development of industry. Approximately 30 million m3 of olive mill wastewater (OMWW) are produced annually in the world as a by-product of the olive oil extraction process. In addition to being a serious environmental and economic issue because of their polluting load, OMWW can also represent a precious resource of high-added-value molecules such as polyphenols that show acclaimed antioxidant and anti-inflammatory activities and can find useful applications in the pharmaceutical industry. In particular, the possibility to develop novel nutraceutical ophthalmic formulations containing free radical scavengers would represent an important therapeutic opportunity for all inflammatory diseases of the ocular surface. In this work, different adsorbents were tested to selectively recover a fraction that is rich in polyphenols from OMWW. Afterward, cytotoxicity and antioxidant/anti-inflammatory activities of polyphenolic fraction were evaluated through in vitro tests. Our results showed that the fraction (0.01%) had no toxic effects and was able to protect cells against oxidant and inflammatory stimulus, reducing reactive oxygen species and TNF-α levels. Finally, a novel stable ophthalmic hydrogel containing a polyphenolic fraction (0.01%) was formulated and the technical and economic feasibility of the process at a pre-industrial level was investigated. View Full-Text
Keywords: olive mill wastewater; polyphenols; valorization; adsorbents; ophthalmic hydrogel; anti-inflammatory and antioxidant activity olive mill wastewater; polyphenols; valorization; adsorbents; ophthalmic hydrogel; anti-inflammatory and antioxidant activity
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Di Mauro, M.D.; Fava, G.; Spampinato, M.; Aleo, D.; Melilli, B.; Saita, M.G.; Centonze, G.; Maggiore, R.; D’Antona, N. Polyphenolic Fraction from Olive Mill Wastewater: Scale-Up and in Vitro Studies for Ophthalmic Nutraceutical Applications. Antioxidants 2019, 8, 462.

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