Next Article in Journal
Carbon Monoxide Partially Mediates Protective Effect of Resveratrol Against UVB-Induced Oxidative Stress in Human Keratinocytes
Next Article in Special Issue
Effects of Resistance Exercise on Cerebral Redox Regulation and Cognition: An Interplay Between Muscle and Brain
Previous Article in Journal
Formononetin Upregulates Nrf2/HO-1 Signaling and Prevents Oxidative Stress, Inflammation, and Kidney Injury in Methotrexate-Induced Rats
Previous Article in Special Issue
Antioxidant and Adaptative Response Mediated by Nrf2 during Physical Exercise
Open AccessArticle

Moderate Intensity Resistive Training Reduces Oxidative Stress and Improves Muscle Mass and Function in Older Individuals

Institute of Clinical Physiology, National Research Council (CNR), ASST Grande Ospedale Metropolitano Niguarda, 20121 Milan, Italy
Department of Human Sciences and Promotion of the Quality of Life, San Raffaele Roma Open University, 20121 Milan, Italy
Institute of Biomedical Technologies, National Research Council (CNR), Segrate, 20121 Milan, Italy
Interfaculty of Education and Medicine, Università Cattolica del Sacro Cuore, 20121 Milan, Italy
Department of Biomedical Sciences for Health, Università degli Studi di Milano, 20133 Milan, Italy
Department of Clinical and Experimental Medicine, University of Parma, 43126 Parma, Italy
Department of Biomedical Sciences, University of Padua, 35122 Padua, Italy
Author to whom correspondence should be addressed.
Antioxidants 2019, 8(10), 431;
Received: 9 September 2019 / Revised: 23 September 2019 / Accepted: 25 September 2019 / Published: 26 September 2019
(This article belongs to the Special Issue Redox Signalling and Exercise)
An innovative moderate-intensity resistive exercise-training (RT) program was tested in thirty-five sarcopenic elders (SAR). The subjects were randomized into two groups: SAR training (SAR-RT), n = 20, 73.0 ± 5.5 years, or SAR non-training (SAR-NT), n = 15, 71.7 ± 3.4 years. The training consisted of 12-week progressive RT, thrice/week, at 60% one-repetition maximum (1RM), 3 sets, 14–16 repetitions for both upper and lower limbs. The pre and post intervention measurements included: the skeletal muscle index (SMI%); strength (1RM); stair-climbing power (SCP); muscle thickness (MT) of vastus lateralis (VL) and elbow flexors (EF), VL pennation angle (PA), rectus femoris (RF) anatomical cross-sectional area (ACSA); reactive oxygen species (ROS), total antioxidant capacity (TAC), protein carbonyls (PC), thiobarbituric acid-reactive substances (TBARS), 8-isoprostane (8-iso-PGF2-α), 8-OH-2-deoxyguanosine (8-OH-dG), as markers of oxidative stress/damage (OxS). In SAR-RT, SCP increased by 7.7% (P < 0.01), MT increased by 5.5% for VL, 10.4% for EF and PA increased by 13.4% for VL (P < 0.001 for all). The RF ACSA increased by 14.5% (P < 0.001). 1RM significantly increased by at least 67% for all muscles tested. Notably muscle strength (1RM) positively correlated (P < 0.001) with TAC and negatively with PC (P < 0.001). In conclusion, moderate intensity RT is an effective strategy to increase muscle mass and strength in SAR, while minimizing OxS. View Full-Text
Keywords: resistive training; muscle mass; muscle strength; oxidative stress resistive training; muscle mass; muscle strength; oxidative stress
Show Figures

Figure 1

MDPI and ACS Style

Vezzoli, A.; Mrakic-Sposta, S.; Montorsi, M.; Porcelli, S.; Vago, P.; Cereda, F.; Longo, S.; Maggio, M.; Narici, M. Moderate Intensity Resistive Training Reduces Oxidative Stress and Improves Muscle Mass and Function in Older Individuals. Antioxidants 2019, 8, 431.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop