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Open AccessArticle

Moderate Intensity Resistive Training Reduces Oxidative Stress and Improves Muscle Mass and Function in Older Individuals

1
Institute of Clinical Physiology, National Research Council (CNR), ASST Grande Ospedale Metropolitano Niguarda, 20121 Milan, Italy
2
Department of Human Sciences and Promotion of the Quality of Life, San Raffaele Roma Open University, 20121 Milan, Italy
3
Institute of Biomedical Technologies, National Research Council (CNR), Segrate, 20121 Milan, Italy
4
Interfaculty of Education and Medicine, Università Cattolica del Sacro Cuore, 20121 Milan, Italy
5
Department of Biomedical Sciences for Health, Università degli Studi di Milano, 20133 Milan, Italy
6
Department of Clinical and Experimental Medicine, University of Parma, 43126 Parma, Italy
7
Department of Biomedical Sciences, University of Padua, 35122 Padua, Italy
*
Author to whom correspondence should be addressed.
Antioxidants 2019, 8(10), 431; https://doi.org/10.3390/antiox8100431
Received: 9 September 2019 / Revised: 23 September 2019 / Accepted: 25 September 2019 / Published: 26 September 2019
(This article belongs to the Special Issue Redox Signalling and Exercise)
An innovative moderate-intensity resistive exercise-training (RT) program was tested in thirty-five sarcopenic elders (SAR). The subjects were randomized into two groups: SAR training (SAR-RT), n = 20, 73.0 ± 5.5 years, or SAR non-training (SAR-NT), n = 15, 71.7 ± 3.4 years. The training consisted of 12-week progressive RT, thrice/week, at 60% one-repetition maximum (1RM), 3 sets, 14–16 repetitions for both upper and lower limbs. The pre and post intervention measurements included: the skeletal muscle index (SMI%); strength (1RM); stair-climbing power (SCP); muscle thickness (MT) of vastus lateralis (VL) and elbow flexors (EF), VL pennation angle (PA), rectus femoris (RF) anatomical cross-sectional area (ACSA); reactive oxygen species (ROS), total antioxidant capacity (TAC), protein carbonyls (PC), thiobarbituric acid-reactive substances (TBARS), 8-isoprostane (8-iso-PGF2-α), 8-OH-2-deoxyguanosine (8-OH-dG), as markers of oxidative stress/damage (OxS). In SAR-RT, SCP increased by 7.7% (P < 0.01), MT increased by 5.5% for VL, 10.4% for EF and PA increased by 13.4% for VL (P < 0.001 for all). The RF ACSA increased by 14.5% (P < 0.001). 1RM significantly increased by at least 67% for all muscles tested. Notably muscle strength (1RM) positively correlated (P < 0.001) with TAC and negatively with PC (P < 0.001). In conclusion, moderate intensity RT is an effective strategy to increase muscle mass and strength in SAR, while minimizing OxS. View Full-Text
Keywords: resistive training; muscle mass; muscle strength; oxidative stress resistive training; muscle mass; muscle strength; oxidative stress
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Vezzoli, A.; Mrakic-Sposta, S.; Montorsi, M.; Porcelli, S.; Vago, P.; Cereda, F.; Longo, S.; Maggio, M.; Narici, M. Moderate Intensity Resistive Training Reduces Oxidative Stress and Improves Muscle Mass and Function in Older Individuals. Antioxidants 2019, 8, 431.

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