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Antioxidants 2018, 7(9), 114; https://doi.org/10.3390/antiox7090114

Physiological Roles of Plant Methionine Sulfoxide Reductases in Redox Homeostasis and Signaling

1
Laboratoire d’Ecophysiologie Moléculaire des Plantes, Aix Marseille University, CEA, CNRS, BIAM, F-13108 Saint Paul-Lez-Durance, France
2
Laboratoire de Bioénergétique Cellulaire, Aix Marseille University, CEA, CNRS, BIAM, F-13108 Saint Paul-Lez-Durance, France
*
Author to whom correspondence should be addressed.
Received: 6 July 2018 / Revised: 24 August 2018 / Accepted: 26 August 2018 / Published: 29 August 2018
(This article belongs to the Special Issue Thioredoxin and Glutaredoxin Systems)
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Abstract

Oxidation of methionine (Met) leads to the formation of two S- and R-diastereoisomers of Met sulfoxide (MetO) that are reduced back to Met by methionine sulfoxide reductases (MSRs), A and B, respectively. Here, we review the current knowledge about the physiological functions of plant MSRs in relation with subcellular and tissue distribution, expression patterns, mutant phenotypes, and possible targets. The data gained from modified lines of plant models and crop species indicate that MSRs play protective roles upon abiotic and biotic environmental constraints. They also participate in the control of the ageing process, as shown in seeds subjected to adverse conditions. Significant advances were achieved towards understanding how MSRs could fulfil these functions via the identification of partners among Met-rich or MetO-containing proteins, notably by using redox proteomic approaches. In addition to a global protective role against oxidative damage in proteins, plant MSRs could specifically preserve the activity of stress responsive effectors such as glutathione-S-transferases and chaperones. Moreover, several lines of evidence indicate that MSRs fulfil key signaling roles via interplays with Ca2+- and phosphorylation-dependent cascades, thus transmitting ROS-related information in transduction pathways. View Full-Text
Keywords: methionine; methionine sulfoxide; methionine sulfoxide reductase; physiological function; protein; plant; repair; redox homeostasis; signaling; stress methionine; methionine sulfoxide; methionine sulfoxide reductase; physiological function; protein; plant; repair; redox homeostasis; signaling; stress
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Rey, P.; Tarrago, L. Physiological Roles of Plant Methionine Sulfoxide Reductases in Redox Homeostasis and Signaling. Antioxidants 2018, 7, 114.

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