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Antioxidants 2018, 7(7), 84;

Transcription Factor ETS-1 and Reactive Oxygen Species: Role in Vascular and Renal Injury

Division of Nephrology and Hypertension, University of Utah, Salt Lake City, UT 84112, USA
Renal Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Renal Division, Weill Cornell Medical College, New York, NY 10065, USA
Author to whom correspondence should be addressed.
Received: 23 April 2018 / Revised: 15 June 2018 / Accepted: 2 July 2018 / Published: 3 July 2018
(This article belongs to the Special Issue Oxidative Stress and Salt-Sensitive Hypertension)
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The E26 avian erythroblastosis virus transcription factor-1 (ETS-1) is a member of the ETS family and regulates the expression of a variety of genes including growth factors, chemokines and adhesion molecules. Although ETS-1 was discovered as an oncogene, several lines of research show that it is up-regulated by angiotensin II (Ang II) both in the vasculature and the glomerulus. While reactive oxygen species (ROS) are required for Ang II-induced ETS-1 expression, ETS-1 also regulates the expression of p47phox, which is one of the subunits of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and a major source of ROS in the kidney and vasculature. Thus, there appears to be a positive feedback between ETS-1 and ROS. ETS-1 is also upregulated in the kidneys of rats with salt-sensitive hypertension and plays a major role in the development of end-organ injury in this animal model. Activation of the renin angiotensin system is required for the increased ETS-1 expression in these rats, and blockade of ETS-1 or haplodeficiency reduces the severity of kidney injury in these rats. In summary, ETS-1 plays a major role in the development of vascular and renal injury and is a potential target for the development of novel therapeutic strategies to ameliorate end-organ injury in hypertension. View Full-Text
Keywords: ETS-1; reactive oxygen species; vascular injury; renal injury ETS-1; reactive oxygen species; vascular injury; renal injury

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Shiu, Y.-T.; Jaimes, E.A. Transcription Factor ETS-1 and Reactive Oxygen Species: Role in Vascular and Renal Injury. Antioxidants 2018, 7, 84.

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