Next Article in Journal
The Effects of Allicin, a Reactive Sulfur Species from Garlic, on a Selection of Mammalian Cell Lines
Next Article in Special Issue
Exercise-Induced Oxidative Stress Responses in the Pediatric Population
Previous Article in Journal
Silymarin Activates c-AMP Phosphodiesterase and Stimulates Insulin Secretion in a Glucose-Dependent Manner in HIT-T15 Cells
Article Menu

Export Article

Open AccessReview
Antioxidants 2016, 5(4), 48;

Role of Redox Signaling and Inflammation in Skeletal Muscle Adaptations to Training

Department of Physiology, Fundacion Investigacion Hospital Clinico Universitario/INCLIVA, University of Valencia, València 46010, Spain
Laboratory of Physiological Hygiene and Exercise Science, School of Kinesiology, University of Minnesota, 1900 University Avenue, Minneapolis, MN 55455, USA
Author to whom correspondence should be addressed.
Academic Editor: Athanasios Jamurtas
Received: 10 October 2016 / Revised: 30 November 2016 / Accepted: 8 December 2016 / Published: 13 December 2016
(This article belongs to the Special Issue Exercise Induced Muscle Damage and Oxidative Stress)
Full-Text   |   PDF [689 KB, uploaded 13 December 2016]   |  


The inflammatory response to exercise-induced muscle damage has been extensively described. Exercise has important modulatory effects on immune function. These effects are mediated by diverse factors including pro-inflammatory cytokines, classical stress hormones, and hemodynamic effects leading to cell redistribution. As has been reported regarding oxidative stress, inflammation can have both detrimental and beneficial effects in skeletal muscle. In this review we will address the role of inflammation on protein metabolism in skeletal muscle. Specifically, we will review studies showing that treatment with cyclooxygenase-inhibiting drugs modulate the protein synthesis response to one bout of resistance exercise and to training. Understanding how these drugs work is important for the millions of individuals worldwide that consume them regularly. We will also discuss the importance of reactive oxygen species and inflammatory cytokines in muscle adaptations to exercise and the Janus faced of the use of antioxidant and anti-inflammatory drugs by athletes for optimizing their performance, especially during the periods in which muscle hypertrophy is expected. View Full-Text
Keywords: oxidative stress; anti-inflammatories; hypertrophy; protein synthesis; prostaglandins oxidative stress; anti-inflammatories; hypertrophy; protein synthesis; prostaglandins

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Gomez-Cabrera, M.C.; Viña, J.; Ji, L.L. Role of Redox Signaling and Inflammation in Skeletal Muscle Adaptations to Training. Antioxidants 2016, 5, 48.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Antioxidants EISSN 2076-3921 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top