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Development of Antioxidant COX-2 Inhibitors as Radioprotective Agents for Radiation Therapy—A Hypothesis-Driven Review
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Antioxidants 2016, 5(3), 22;

Protection against Radiotherapy-Induced Toxicity

Menzies Health Institute Queensland, Griffith University, Gold Coast 4222, Australia
School of Pharmacy, Griffith University, Gold Coast 4222, Australia
Centre for Urology Research, Faculty of Health Sciences and Medicine, Bond University, Robina 4226, Australia
Author to whom correspondence should be addressed.
Academic Editor: Alexandros G. Georgakilas
Received: 30 May 2016 / Revised: 27 June 2016 / Accepted: 28 June 2016 / Published: 5 July 2016
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Radiation therapy is a highly utilized therapy in the treatment of malignancies with up to 60% of cancer patients receiving radiation therapy as a part of their treatment regimen. Radiation therapy does, however, cause a wide range of adverse effects that can be severe and cause permanent damage to the patient. In an attempt to minimize these effects, a small number of compounds have been identified and are in use clinically for the prevention and treatment of radiation associated toxicities. Furthermore, there are a number of emerging therapies being developed for use as agents that protect against radiation-induced toxicities. The aim of this review was to evaluate and summarise the evidence that exists for both the known radioprotectant agents and the agents that show promise as future radioprotectant agents. View Full-Text
Keywords: radiotherapy; toxicity; oxidative stress; inflammation radiotherapy; toxicity; oxidative stress; inflammation

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Hall, S.; Rudrawar, S.; Zunk, M.; Bernaitis, N.; Arora, D.; McDermott, C.M.; Anoopkumar-Dukie, S. Protection against Radiotherapy-Induced Toxicity. Antioxidants 2016, 5, 22.

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