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Development of Antioxidant COX-2 Inhibitors as Radioprotective Agents for Radiation Therapy—A Hypothesis-Driven Review

1
Department of Radiopharmaceutical and Chemical Biology, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Bautzner Landstrasse 400, Dresden D-01328, Germany
2
Department of Chemistry and Food Chemistry, Technische Universität Dresden, Dresden D-01062, Germany
*
Authors to whom correspondence should be addressed.
Academic Editor: Alexandros G. Georgakilas
Antioxidants 2016, 5(2), 14; https://doi.org/10.3390/antiox5020014
Received: 15 March 2016 / Revised: 8 April 2016 / Accepted: 11 April 2016 / Published: 19 April 2016
Radiation therapy (RT) evolved to be a primary treatment modality for cancer patients. Unfortunately, the cure or relief of symptoms is still accompanied by radiation-induced side effects with severe acute and late pathophysiological consequences. Inhibitors of cyclooxygenase-2 (COX-2) are potentially useful in this regard because radioprotection of normal tissue and/or radiosensitizing effects on tumor tissue have been described for several compounds of this structurally diverse class. This review aims to substantiate the hypothesis that antioxidant COX-2 inhibitors are promising radioprotectants because of intercepting radiation-induced oxidative stress and inflammation in normal tissue, especially the vascular system. For this, literature reporting on COX inhibitors exerting radioprotective and/or radiosensitizing action as well as on antioxidant COX inhibitors will be reviewed comprehensively with the aim to find cross-points of both and, by that, stimulate further research in the field of radioprotective agents. View Full-Text
Keywords: COX-2 inhibitors (COXIBs); cyclooxygenases; normal tissue; nonsteroidal anti-inflammatory drugs (NSAIDS); oxidative stress; radiation-induced vascular dysfunction; radioprotection; radiosensitization; reactive oxygen/nitrogen species; tumor models COX-2 inhibitors (COXIBs); cyclooxygenases; normal tissue; nonsteroidal anti-inflammatory drugs (NSAIDS); oxidative stress; radiation-induced vascular dysfunction; radioprotection; radiosensitization; reactive oxygen/nitrogen species; tumor models
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MDPI and ACS Style

Laube, M.; Kniess, T.; Pietzsch, J. Development of Antioxidant COX-2 Inhibitors as Radioprotective Agents for Radiation Therapy—A Hypothesis-Driven Review. Antioxidants 2016, 5, 14.

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