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Berry Leaves: An Alternative Source of Bioactive Natural Products of Nutritional and Medicinal Value

Laboratory of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, University of Patras, Patras 26504, Greece
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Author to whom correspondence should be addressed.
Dedicated to the memory of the late Professor Paul Cordopatis, a dedicated scientist and a great mentor.
Academic Editor: Dorothy Klimis-Zacas
Antioxidants 2016, 5(2), 17; https://doi.org/10.3390/antiox5020017
Received: 1 February 2016 / Revised: 29 April 2016 / Accepted: 10 May 2016 / Published: 1 June 2016
(This article belongs to the Special Issue Berry Antioxidants in Health and Disease)
Berry fruits are recognized, worldwide, as “superfoods” due to the high content of bioactive natural products and the health benefits deriving from their consumption. Berry leaves are byproducts of berry cultivation; their traditional therapeutic use against several diseases, such as the common cold, inflammation, diabetes, and ocular dysfunction, has been almost forgotten nowadays. Nevertheless, the scientific interest regarding the leaf composition and beneficial properties grows, documenting that berry leaves may be considered an alternative source of bioactives. The main bioactive compounds in berry leaves are similar as in berry fruits, i.e., phenolic acids and esters, flavonols, anthocyanins, and procyanidins. The leaves are one of the richest sources of chlorogenic acid. In various studies, these secondary metabolites have demonstrated antioxidant, anti-inflammatory, cardioprotective, and neuroprotective properties. This review focuses on the phytochemical composition of the leaves of the commonest berry species, i.e., blackcurrant, blackberry, raspberry, bilberry, blueberry, cranberry, and lingonberry leaves, and presents their traditional medicinal uses and their biological activities in vitro and in vivo. View Full-Text
Keywords: Vaccinium; Ribes; Rubus; traditional use; polyphenols; chlorogenic acid; analysis Vaccinium; Ribes; Rubus; traditional use; polyphenols; chlorogenic acid; analysis
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Ferlemi, A.-V.; Lamari, F.N. Berry Leaves: An Alternative Source of Bioactive Natural Products of Nutritional and Medicinal Value. Antioxidants 2016, 5, 17.

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