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Antioxidants 2014, 3(4), 830-842;

Rosmarinic Acid, a New Polyphenol from Baccaurea ramiflora Lour. Leaf: A Probable Compound for Its Anti-Inflammatory Activity

Department of Biotechnology, Maharani Lakshmi Ammanni College for Women, Bangalore-560012, India
Department of Botany, Kalimpong College, Kalimpong-734301, India
Padmashree Institute of Management and Science, Bangalore-560060, India
Bamboo Technology, Department of Biotechnology, Bodoland University, Kokrajhar-783370, India
Author to whom correspondence should be addressed.
Received: 11 August 2014 / Revised: 20 November 2014 / Accepted: 20 November 2014 / Published: 3 December 2014
(This article belongs to the Special Issue Analytical Determination of Polyphenols)
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Despite several pharmacological applications of Baccaurea ramiflora Lour., studies on the influence of its polyphenol content on pharmacological activity such as anti-inflammatory properties have been scarce. Here we evaluated in vitro antioxidant activity, poyphenolics by HPLC and the anti-inflammatory potential of the methanolic leaf extract of Baccaurea ramiflora (BME) and its protective effects in carrageenan-induced paw edema model of inflammation in rats. The BME extract contained 79.06 ± 0.03 mg gallic acid equivalent (GAE)/g total polyphenols, 28.80 ± 0.01 mg quercetin equivalent (QE)/g flavonoid and 29.42 ± 0.01 μg cathechin equivalent/g proanthocyanidin respectively and rosmarinic acid (8 mg/kg) as a main component was identified by HPLC. Results demonstrate that administration of BME at the dose of 200 mg/kg can reduce paw edema by over 63%, and it exhibits a dose-response effect. Depending on concentration, the extract exerted scavenging activity on DPPH radical (IC50 36.4 μg/mL), significantly inhibited IL-1β (4.4 pg/mg protein) and TNF-α (0.21 ng/μg protein). Therefore, we conclude BME causes a substantial reduction of inflammation in in vivo models. We propose that rosmarinic acid and similar phenolic compounds may be useful in the therapy of inflammation-related injuries. View Full-Text
Keywords: Baccaurea ramiflora; rosmarinic acid; anti-inflammatory activity; cytokines Baccaurea ramiflora; rosmarinic acid; anti-inflammatory activity; cytokines

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Usha, T.; Middha, S.K.; Bhattacharya, M.; Lokesh, P.; Goyal, A.K. Rosmarinic Acid, a New Polyphenol from Baccaurea ramiflora Lour. Leaf: A Probable Compound for Its Anti-Inflammatory Activity. Antioxidants 2014, 3, 830-842.

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