Mitochondrial Fission as a Therapeutic Target for Metabolic Diseases: Insights into Antioxidant Strategies
Abstract
:1. Introduction
2. Reactive Oxygen Species: Physiology, Pathology, and Therapeutic Potential
2.1. ROS Generation and Metabolism
2.2. Physiological ROS Signaling
2.3. The Role of ROS in Metabolic Diseases
2.4. Therapeutic Potential of ROS
3. Mitochondrial Fission Mechanism and Implications for Metabolic Diseases
3.1. Overview of Mitochondrial Membrane Structure and Dynamics
3.2. Mitochondrial Fission Mediator Drp1 and Its Regulation
3.3. Pathological Role of Mitochondrial Fission in Metabolic Diseases—The Interplay between Mitochondria and ROS
4. Target Mitochondrial Fission for Antioxidants in Metabolic Diseases
4.1. Effect of Lifestyle on Mitochondrial Fission and ROS
4.2. Effect of Dietary Supplements on Mitochondrial Fission and ROS
4.3. Drp1 Chemical Inhibitors
4.4. Effect of Metabolic Disease Drugs on Mitochondrial Fission and ROS
5. Conclusions and Perspectives
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Yu, T.; Wang, L.; Zhang, L.; Deuster, P.A. Mitochondrial Fission as a Therapeutic Target for Metabolic Diseases: Insights into Antioxidant Strategies. Antioxidants 2023, 12, 1163. https://doi.org/10.3390/antiox12061163
Yu T, Wang L, Zhang L, Deuster PA. Mitochondrial Fission as a Therapeutic Target for Metabolic Diseases: Insights into Antioxidant Strategies. Antioxidants. 2023; 12(6):1163. https://doi.org/10.3390/antiox12061163
Chicago/Turabian StyleYu, Tianzheng, Li Wang, Lei Zhang, and Patricia A. Deuster. 2023. "Mitochondrial Fission as a Therapeutic Target for Metabolic Diseases: Insights into Antioxidant Strategies" Antioxidants 12, no. 6: 1163. https://doi.org/10.3390/antiox12061163