The Complex Genetic and Epigenetic Regulation of the Nrf2 Pathways: A Review
Abstract
:1. Introduction
2. The Nrf2 Activation Pathway
3. The Complexity of the Nrf2 Pathway Tells Us “One Size Does Not Fit All”
4. MST1 Presents an Intriguing Alternative Route to Nrf2 Activation
5. Local Control May Selectively Regulate Nrf2 Effects That Are Context-Dependent
6. Can the Activation Pathway Affect the Gene Expression Profile?
7. Network Pharmacology Versus the “One Gene, One Drug, One Disease” Paradigm
8. Future Directions
9. Conclusions
Funding
Conflicts of Interest
References
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McCord, J.M.; Gao, B.; Hybertson, B.M. The Complex Genetic and Epigenetic Regulation of the Nrf2 Pathways: A Review. Antioxidants 2023, 12, 366. https://doi.org/10.3390/antiox12020366
McCord JM, Gao B, Hybertson BM. The Complex Genetic and Epigenetic Regulation of the Nrf2 Pathways: A Review. Antioxidants. 2023; 12(2):366. https://doi.org/10.3390/antiox12020366
Chicago/Turabian StyleMcCord, Joe M., Bifeng Gao, and Brooks M. Hybertson. 2023. "The Complex Genetic and Epigenetic Regulation of the Nrf2 Pathways: A Review" Antioxidants 12, no. 2: 366. https://doi.org/10.3390/antiox12020366