Next Article in Journal
Carnitines as Mitochondrial Modulators of Oocyte and Embryo Bioenergetics
Next Article in Special Issue
Structural Characterization of Two Short Unspecific Peroxygenases: Two Different Dimeric Arrangements
Previous Article in Journal
Multicentric Standardization of Protocols for the Diagnosis of Human Mitochondrial Respiratory Chain Defects
Previous Article in Special Issue
A Unique P450 Peroxygenase System Facilitated by a Dual-Functional Small Molecule: Concept, Application, and Perspective
Article

Novel Fatty Acid Chain-Shortening by Fungal Peroxygenases Yielding 2C-Shorter Dicarboxylic Acids

1
Instituto de Recursos Naturales y Agrobiología de Sevilla, CSIC, Av. Reina Mercedes 10, 41012 Seville, Spain
2
Unit of Bio- and Environmental Sciences, TU Dresden, International Institute Zittau, Markt 23, 02763 Zittau, Germany
3
Centro de Investigaciones Biológicas “Margarita Salas”, CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Stanley Omaye
Antioxidants 2022, 11(4), 744; https://doi.org/10.3390/antiox11040744
Received: 10 March 2022 / Revised: 29 March 2022 / Accepted: 7 April 2022 / Published: 8 April 2022
(This article belongs to the Special Issue Dream Peroxygenases)
Unspecific peroxygenases (UPOs), the extracellular enzymes capable of oxygenating a potpourri of aliphatic and aromatic substrates with a peroxide as co-substrate, come out with a new reaction: carbon-chain shortening during the conversion of fatty acids with the well-known UPOs from Coprinopsis cinerea (rCciUPO) and Cyclocybe (Agrocybe) aegerita (AaeUPO). Although a pathway (Cα-oxidation) for shortening the hydrocarbon chain of saturated fatty acids has already been reported for the UPO from Marasmius rotula (MroUPO), it turned out that rCciUPO and AaeUPO shorten the chain length of both saturated and unsaturated fatty acids in a different way. Thus, the reaction sequence does not necessarily start at the Cα-carbon (adjacent to the carboxyl group), as in the case of MroUPO, but proceeds through the subterminal (ω-1 and ω-2) carbons of the chain via several oxygenations. This new type of shortening leads to the formation of a dicarboxylic fatty acid reduced in size by two carbon atoms in the first step, which can subsequently be further shortened, carbon by carbon, by the UPO Cα-oxidation mechanism. View Full-Text
Keywords: chain shortening; fatty acids; peroxygenation; EC 1.11.2.1; Coprinopsis cinerea; Agrocybe aegerita; fungal enzymes chain shortening; fatty acids; peroxygenation; EC 1.11.2.1; Coprinopsis cinerea; Agrocybe aegerita; fungal enzymes
Show Figures

Figure 1

MDPI and ACS Style

Olmedo, A.; Ullrich, R.; Hofrichter, M.; del Río, J.C.; Martínez, Á.T.; Gutiérrez, A. Novel Fatty Acid Chain-Shortening by Fungal Peroxygenases Yielding 2C-Shorter Dicarboxylic Acids. Antioxidants 2022, 11, 744. https://doi.org/10.3390/antiox11040744

AMA Style

Olmedo A, Ullrich R, Hofrichter M, del Río JC, Martínez ÁT, Gutiérrez A. Novel Fatty Acid Chain-Shortening by Fungal Peroxygenases Yielding 2C-Shorter Dicarboxylic Acids. Antioxidants. 2022; 11(4):744. https://doi.org/10.3390/antiox11040744

Chicago/Turabian Style

Olmedo, Andrés, René Ullrich, Martin Hofrichter, José C. del Río, Ángel T. Martínez, and Ana Gutiérrez. 2022. "Novel Fatty Acid Chain-Shortening by Fungal Peroxygenases Yielding 2C-Shorter Dicarboxylic Acids" Antioxidants 11, no. 4: 744. https://doi.org/10.3390/antiox11040744

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop