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Review

Bio-Availability, Anticancer Potential, and Chemical Data of Lycopene: An Overview and Technological Prospecting

1
Rede Nordeste de Biotecnologia, RENORBIO, Campus Ministro Petrônio Portela, Universidade Federal do Piauí, UFPI, Teresina 64049-550, PI, Brazil
2
Núcleo de Pesquisa em Morfologia e Imunologia Aplicada, NuPMIA, Área de Morfologia, Faculdade de Medicina, Universidade de Brasília, UnB, Brasilia 70190-900, DF, Brazil
3
Centro Universitário do Distrito Federal, UDF, Brasília 70390-045, DF, Brazil
4
People&Science, Brasília 70340-908, DF, Brazil
5
Laboratório de Cultura de Célula do Delta, LCC Delta, Universidade Federal do Delta do Parnaíba, UFDPar, Parnaiba 64202-020, PI, Brazil
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Laboratório Associado, Centro de Biotecnologia e Química Fina, CBQF-ESB, Universidade Católica Portuguesa, 4169-005 Porto, Portugal
7
Departamento de Ingeniería Química, Facultad de Ciencias, Campus Ourense, Universidad de Vigo, As Lagoas, 32004 Ourense, Spain
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Stanley Omaye
Antioxidants 2022, 11(2), 360; https://doi.org/10.3390/antiox11020360
Received: 9 January 2022 / Revised: 30 January 2022 / Accepted: 8 February 2022 / Published: 11 February 2022
The purpose of this review was to collect relevant chemical data about lycopene and its isomers, which can be extracted using different non-polar or polar aprotic solvents by SC-CO2 or biosynthesis as a friendly technique. Lycopene and other carotenoids can be identified and quantified by UV–Vis and HPLC using a C18 or C30 column, while their characterization is possible by UV–Vis, Fluorescence, FTIR, MS, NMR, and DSC assays. Among these techniques, the last four can compare lycopene isomers and identify cis or all-trans-lycopene. FTIR, MS, and NMR techniques are more suitable for the verification of the purity of lycopene extracts due to the signal complexity generated for each isomer, which enables identification by subtle differences. Additionally, some biological activities of lycopene isolated from red vegetables have already been confirmed, such as anti-inflammatory, antioxidant, and cytotoxic activity against cancer cells, probably by activating several pathways. The encapsulation of lycopene in nanoparticles demonstrated an improvement in oral delivery, and ex vivo assessments determined that these nanoparticles had better permeation and low cytotoxicity against human cells with enhanced permeation. These data suggest that lycopene has the potential to be applied in the food and pharmaceutical industries, as well as in cosmetic products. View Full-Text
Keywords: anti-inflammatory; bio-availability; cancer; lycopene; nanostructure anti-inflammatory; bio-availability; cancer; lycopene; nanostructure
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MDPI and ACS Style

Amorim, A.d.G.N.; Vasconcelos, A.G.; Souza, J.; Oliveira, A.; Gullón, B.; de Souza de Almeida Leite, J.R.; Pintado, M. Bio-Availability, Anticancer Potential, and Chemical Data of Lycopene: An Overview and Technological Prospecting. Antioxidants 2022, 11, 360. https://doi.org/10.3390/antiox11020360

AMA Style

Amorim AdGN, Vasconcelos AG, Souza J, Oliveira A, Gullón B, de Souza de Almeida Leite JR, Pintado M. Bio-Availability, Anticancer Potential, and Chemical Data of Lycopene: An Overview and Technological Prospecting. Antioxidants. 2022; 11(2):360. https://doi.org/10.3390/antiox11020360

Chicago/Turabian Style

Amorim, Adriany d.G.N., Andreanne G. Vasconcelos, Jessica Souza, Ana Oliveira, Beatriz Gullón, José R. de Souza de Almeida Leite, and Manuela Pintado. 2022. "Bio-Availability, Anticancer Potential, and Chemical Data of Lycopene: An Overview and Technological Prospecting" Antioxidants 11, no. 2: 360. https://doi.org/10.3390/antiox11020360

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