Novel Therapeutic Approaches Enhance PGC1-alpha to Reduce Oxidant Stress-Inflammatory Signaling and Improve Functional Recovery in Hibernating Myocardium
Abstract
:1. Introduction
2. Hibernating Myocardium and Revascularization
3. PGC1-alpha Is a Key Mediator of Mitochondrial Energy Metabolism
4. PGC1-alpha Regulates Oxidative Stress and Biogenesis
5. PGC1-alpha Links Cellular Metabolism and Inflammation in the Ischemic Heart
6. Enhanced PGC1-alpha Signaling Improves Recovery in Hibernating Myocardium
7. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Type | Intervention | Model | Sample | Biopsied Tissue | Reference |
---|---|---|---|---|---|
Lifestyle-based | Exercise | Human | n = 7 | Skeletal Muscle | [78] |
Dietary | CoQ10 | Swine | n = 12 | Myocardium | [75] |
Pharmacological | Pioglitazone | Swine | n = 18 | Myocardium | [74] |
Cell-therapeutic | Mesenchymal Stem Cells | Swine | n = 12 | Myocardium | [79] |
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Aggarwal, R.; Potel, K.N.; McFalls, E.O.; Butterick, T.A.; Kelly, R.F. Novel Therapeutic Approaches Enhance PGC1-alpha to Reduce Oxidant Stress-Inflammatory Signaling and Improve Functional Recovery in Hibernating Myocardium. Antioxidants 2022, 11, 2155. https://doi.org/10.3390/antiox11112155
Aggarwal R, Potel KN, McFalls EO, Butterick TA, Kelly RF. Novel Therapeutic Approaches Enhance PGC1-alpha to Reduce Oxidant Stress-Inflammatory Signaling and Improve Functional Recovery in Hibernating Myocardium. Antioxidants. 2022; 11(11):2155. https://doi.org/10.3390/antiox11112155
Chicago/Turabian StyleAggarwal, Rishav, Koray N. Potel, Edward O. McFalls, Tammy A. Butterick, and Rosemary F. Kelly. 2022. "Novel Therapeutic Approaches Enhance PGC1-alpha to Reduce Oxidant Stress-Inflammatory Signaling and Improve Functional Recovery in Hibernating Myocardium" Antioxidants 11, no. 11: 2155. https://doi.org/10.3390/antiox11112155